DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slik and Slk

DIOPT Version :9

Sequence 1:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_033315.2	Gene:	Slk / 20874	MGIID:	103241	Length:	1233	Species:	Mus musculus

Alignment Length:	1389	Identity:	478/1389 - (34%)
Similarity:	712/1389 - (51%)	Gaps:	252/1389 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65
            |||. |.:|:|.|  |..|||:.|.::|.|.:|.||||::|||||||||||||||:||....|||
Mouse     1 MSFF-NFRKIFKL--GSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAA 62

  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130
            |:...:.||.|.|:|||||||:...|||||:|.:||..::.||:|||:|.|||:|::|:|||:||
Mouse    63 KVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127

  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195
            ||.||..|||...|.|.:||.||:|||||||||:|.|::|.:|||||||||||..|:|:.|:|||
Mouse   128 TESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192

  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260
            ||||||||:|:|||.:|.|||:|.|:|||||||||:|::|||:.|::||||||||.|||||.|.|
Mouse   193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQ 257

  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDA-KPIKDLLLEYKAEVVEEVVDDET 324
            ||:||..|.|||:|.|.|:...|.||..|:||.|:  .:|: ||:::|:.|.||||.|||.|.:.
Mouse   258 PSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV--TVDSNKPVRELIAEAKAEVTEEVEDGKE 320

  Fly   325 EEPRNSALQLDLDDDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTK 389
            |:                                     |:.:..::|||.|...|::..:..
Mouse   321 ED-------------------------------------EEEEAENALPIPANKRASSDLSIA-- 346

  Fly   390 ATTPDRPNHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPPAQPTAAVLQKKPEDV 454
                                             ||::....|           .|.:|:
Mouse   347 ---------------------------------SSEEDKLSQ-----------NACILE------ 361

  Fly   455 AAVAETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPA------ASDSQTSPKKLATPEPTSPVT 513
             :|:|.:|::.|:.| |..|           :.|.||.      |.|...|...|.|....:..|
Mouse   362 -SVSERTEQSTSEDK-FSNK-----------ILNEKPTTDGPEKAVDEHASDVNLETGAELNDQT 413

  Fly   514 TAIEVAIGQEAMEPKPQP-PSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHH 577
            ..|. ..|:|...||.:. |.......|.|.||:..:.:..|:   |.::|..:.
Mouse   414 VGIH-ENGREKKRPKLENLPDTQDQQTVDVNSVSEENENNRVT---LETNTDCLK---------- 464

  Fly   578 HQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSNDMNKSTHL------ 636
                |.:.::.....:|||                          .:|.|.::| .||:
Mouse   465 ----PEEDRNKENQETLES--------------------------KLIQSEEIN-DTHIQTMDLV 498

  Fly   637 --HESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSSTVHARKL---DE 696
              .....:.||.::|:.:|             |...|         :|.:......|:|:   |.
Mouse   499 SQETGEKEADFQAVDNEVG-------------LTKEE---------TQEKLGKDGTAQKVITSDR 541

  Fly   697 SEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVS-VVTVGDE----------GVKVKDSS 750
            |..:....:..|...|...:..:.|.:..:.|..|..:: ..|.|.|          |.:|:|..
Mouse   542 SSEVGTDEALDDTQKAAELSKAAQSGEGDEALAPTQTLAEKPTEGPEAGGAEEEPPGGERVEDKQ 606

  Fly   751 NELVKRQP---NGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSG---GSD 809
            .|   :||   ...|.:...........:|.:......:||:.|:.....: |:.|...   ||:
Mouse   607 PE---QQPAVCEAEGQLTSTSETTRATLEQPETDEVEQVSESNSIEELERL-VVTGAEARALGSE 667

  Fly   810 VDSIGTNTS---QESRHETDHNNKQQYPAAALMPPPPPSL--TNNHNHETIDEEEEVVIRPKARV 869
            .::..|...   :|:..:.....:.|.|||:....|.|.|  :.|.|.||.:.:||:...||...
Mouse   668 GEAAATEVDLERKENAQKVPVKAESQAPAASQPSEPHPVLIPSININSETTENKEEMGALPKPET 732

  Fly   870 -----PAVVKS-----------ANAQG---------LTKEE----IELRNLR--KKTRKRTRKFE 903
                 |...|.           .|:.|         |:|.:    :.|:..|  |||.|:||||.
Mouse   733 ILPPEPEHEKGNDTDSGTGSTVENSSGDLNLSISSFLSKAKDSGSVSLQETRRQKKTLKKTRKFI 797

  Fly   904 IDGVQMTTTTSRVIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRR 968
            :|||:::.|||:::  .|.:.:..:....|:||||||:||||:|::.|.:|:.|.||.:||..||
Mouse   798 VDGVEVSVTTSKIV--TDSDSKTEELRFLRRQELRELRLLQKEEQRAQQQLNGKLQQQREQIFRR 860

  Fly   969 FEQERSSLEKTYEADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIR 1033
            ||||..|.::.|:.:::.|.:|.||.:|:.||...|.||..:|||:.|||:||..|:..||...:
Mouse   861 FEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNVLKNRKK 925

  Fly  1034 LLKQEVDLFPKDKRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRN 1098
            .:..||:..|::.|::..|:|:..:......:|:.|:...::..:..|:::.::.:..||.|.|.
Mouse   926 EVMNEVEKAPRELRRELTKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERE 990

  Fly  1099 FLQQKQNAMRTREALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKE 1163
            .|..||..||.|||.:|||||:.|.|:|||.|:.:|:..||||||::.|||||.:|::|..||..
Mouse   991 CLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLI 1055

  Fly  1164 EDMVKKQTMEKRALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERR 1228
            |::..:||.|:..|||..|:|.|.|..||::||||::...|:.:|:::|:|..||:||...|...
Mouse  1056 EELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMA 1120

  Fly  1229 FEVKHQKQLEELRATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQ 1293
            ...||:.|:.:|:...|:.::||.||||||...|||||..||.|:||....||:||||:|.|||:
Mouse  1121 QHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKK 1185

  Fly  1294 ELNRQIKLAIDQHEKRFGLVTNRE 1317
            .|..:....:.:.|..|.:....|
Mouse  1186 TLEEEFARKLQEQEVFFKMTGESE 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	172/279 (62%)
		S_TKc	37..295	CDD:214567	164/257 (64%)
		PKK	958..1095	CDD:289257	44/136 (32%)
		PKK	1126..1266	CDD:289257	62/139 (45%)
Slk	NP_033315.2	STKc_SLK	28..309	CDD:270811	173/282 (61%)
		S_TKc	34..292	CDD:214567	164/257 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		16/113 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..453		26/102 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..650		30/176 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..761		23/97 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..791		5/18 (28%)
		PKK	850..988	CDD:289257	44/137 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..963		4/18 (22%)
		PKK	1018..1158	CDD:289257	62/139 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1129		7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	353	1.000	Domainoid score	I998
eggNOG	1	0.900	-	-		E1_KOG0579
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	756	1.000	Inparanoid score	I558
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49250
OrthoDB	1	1.010	-	-		D365746at33208
OrthoFinder	1	1.000	-	-		FOG0002520
OrthoInspector	1	1.000	-	-		otm44083
orthoMCL	1	0.900	-	-		OOG6_105446
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3487
SonicParanoid	1	1.000	-	-		X1895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870