Protein Alignment Slik and MAP4K1

DIOPT Version :10

• Sequence 1: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_011524706.1
• Gene: MAP4K1 / 11184
• HGNCID: 6863
• Length: 861
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 197/696 - (28%)
• Similarity: 312/696 - (44%)
• Gaps: 151/696 - (21%)

  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVE 96
            ||.:.::::..||.|.:|:|:||:.|......|.||.::|.::::|....||.||...:|.|||.
Human    12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVA 76

  Fly    97 LYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKA 161
            .:.::....|||:.:|:|..|:|..| .::...|:|.||:|||:.:.:||.:||..|.||||:|.
Human    77 YHGSYLWLQKLWICMEFCGAGSLQDI-YQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKG 140

  Fly   162 GNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGI 226
            .|:|:...|.|:|||||:||:...|:.:..:|||||||||||:.....  ...|:...|||||||
Human   141 ANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAL--KGGYNELCDIWSLGI 203

  Fly   227 TLIELAQMEPPNSEMSPMRVLLKIQKS--EPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVL 289
            |.||||:::||..::.|:|||..:.||  :||:|::..:||..|::|:|.:|.|.|:.||:...:
Human   204 TAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKM 268

  Fly   290 MQHAFI-----NRNLDAKPIKDLLLEY----KAEVVEEVVDDETEEPRNSALQLDLDDDSASLQS 345
            :.|..:     ||.|    |.|||.:.    |...:.::.|:|.|.|.....::.....|:||..
Human   269 LSHQLVSQPGLNRGL----ILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGI 329

  Fly   346 QDID---------KLPGTPTSILRDAKEQSQPSSSLPIAAAATAAAAATTTTKATTPDRP-NHTK 400
            .|.|         ||.|..|          :|       .|.||........::::|.:. :.:.
Human   330 PDADCCRRHMEFRKLRGMET----------RP-------PANTARLQPPRDLRSSSPRKQLSESS 377

  Fly   401 DDNAE------AAAQQPPHTKVPAP-APPSSQQTPP-PQVQQPPTPPAQPTAAVLQKKPEDVAAV 457
            ||:.:      ....:.|..::.:| :.|:||..|| ....:|...|:.||.|      ||.
Human   378 DDDYDDVDMLNLGTWKSPKDQILSPRSRPNSQPRPPYSPAHRPSQAPSSPTPA------EDT--- 433

  Fly   458 AETSEKTESDKKHFVKKGKAPPPPSPLGLANAKPA-ASDSQTSPKKLATPEPTSPVTTAIEVAIG 521
                                 |||.|     .||. .|.|...|..:......|| ...:..|.|
Human   434 ---------------------PPPLP-----PKPKFRSPSDEGPGSMGDDGQLSP-GVLVRCASG 471

  Fly   522 QEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTSLITINSDPPTPHHHQP--LPPQ 584
            .....|:|.||..|:|..::..|..|.                     .:||:....:|  |||:
Human   472 PPPNSPRPGPPPSTSSPHLTAHSEPSL---------------------WNPPSRELDKPPLLPPK 515

  Fly   585 PQHL------IL-------PNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVS-NDMNKSTH 635
            .:.:      :|       |..:.|.:     ..|||.....:.::..:..:.|:: ||
Human   516 KEKMKRKGCALLVKLFNGCPLRIHSTA-----AWTHPSTKDQHLLLGAEEGIFILNRND------ 569

  Fly   636 LHESSTDDDFPSLDD----------SLGDATTPPHKQSSMILAVNE 671
             .|::.:..|||...          ||...|  ||..|..||.:.|
Human   570 -QEATLEMLFPSRTTWVYSINNVLMSLSGKT--PHLYSHSILGLLE 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	113/284 (40%)
		PKK	958..1095	CDD:463600
		PKK	1126..1266	CDD:463600
MAP4K1	XP_011524706.1	STKc_MAP4K3_like	16..274	CDD:270788	104/260 (40%)
		CNH	540..847	CDD:214481	20/87 (23%)