DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF148 and SPBP4H10.07

DIOPT Version :9

Sequence 1:	NP_932351.1	Gene:	RNF148 / 378925	HGNCID:	22411	Length:	305	Species:	Homo sapiens
Sequence 2:	NP_596181.1	Gene:	SPBP4H10.07 / 2541304	PomBaseID:	SPBP4H10.07	Length:	583	Species:	Schizosaccharomyces pombe

Alignment Length:	410	Identity:	78/410 - (19%)
Similarity:	130/410 - (31%)	Gaps:	145/410 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    11 HSSVS------SGLLRLSIFLLLSFPDSNGKAIWTAHLNITFQVGNEITSELGESGVFGNHSPLE 69
            |.||:      :.:.||.:..:.|..|||.:....|.:|   .:.|...::  ::.|....|.|.
pombe   183 HGSVNNLESPGTAIGRLPVRSVTSLADSNMEDYTRAVMN---YINNSENTQ--QASVSPEESQLV 242

Human    70 RVSG-VVALPEGW-----NQNACHPLTNFSRPKQA-----------DSWLALIERGGCTFTHKIN 117
            .:|. |.::..||     |.::.|...|...|...           |.:|:|:..|  .....:|
pombe   243 MLSRFVFSVASGWVSVLMNSSSAHQSNNLEFPSSISGNVESGNVAFDEFLSLLHAG--NLVQAMN 305

Human   118 V-----AAEKGANGVIIYNYQGTGS--KVFPM-----SHQGTENIVAVMISNLKGME-------- 162
            .     .||..||.|.:....|..:  :.|..     :|:|.| ::.::|..::.:.
pombe   306 AETNPRTAELIANAVDLEEESGPINLFRTFRFDNLHRNHEGQE-VIPIIIVGIRSLRNSGSDEDD 369

Human   163 --------ILH--------------------------------SIQKGVYVTVIIEVG------- 180
                    ::|                                .|.:....:...:|.
pombe   370 QPSADSPTLMHPSDLISSLVNSQNQTTSVSDNTGPNENVNEAEHISEDEQASTATDVNGISDNNG 434

Human   181 ---------RMHMQWVSHYIMYLFTFLAATIAYFYLDCVWRLTPR---VP-NSFTRRRSQIKTDV 232
                     |.:.....|                .|...|.:..|   || |....|...:.||.
pombe   435 SSTQQAPETRNNNSQTDH----------------QLPRSWAIYVREAFVPQNHPVLRAPSLFTDS 483

Human   233 KKAIDQLQLR---------VLKEGDEE-------LDLNEDNCVVCFDTYKPQDVVRIL-TCKHFF 280
            ....|.|.|.         |..:.|.|       ....::.|:||...::..|..|.| .|.|||
pombe   484 PTYEDMLLLNSIIGIEKPPVASQKDLEKAGGVFPFSGTDERCLVCLSNFELNDECRRLKQCNHFF 548

Human   281 HKACIDPWLL-AHRTCPMCK 299
            |:.|||.||. :..:||:|:
pombe   549 HRECIDQWLTSSQNSCPLCR 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF148	NP_932351.1	PA_GRAIL_like	43..177	CDD:239037	31/210 (15%)
RNF148	NP_932351.1	zf-RING_2	256..299	CDD:290367	18/44 (41%)
SPBP4H10.07	NP_596181.1	PHA03328	77..>156	CDD:223046
		zf-rbx1	<522..568	CDD:289448	18/45 (40%)
		RING	525..570	CDD:238093	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53615
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1977
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940