Protein Alignment mAChR-A and Hrh3

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001257495.1
• Gene: Hrh3 / 85268
• RGDID: 620630
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 688
• Identity: 140/688 - (20%)
• Similarity: 214/688 - (31%)
• Gaps: 316/688 - (45%)

  Fly    77 PYSGMYGNQTNGTIGFETK---GPR-YSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQT 137
            |..|:.  ..:||:..|..   |.| :|.|...|:..:.|:|...||.||.:||::|..|..|:|
  Rat     5 PPDGLM--NASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRT 67

  Fly   138 ISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDR 202
            .:|:||.:|||:||.:||..:||:....:.|.|..|..:|..||.:|||...:||.|:::||:||
  Rat    68 QNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDR 132

  Fly   203 YFSVTRPLTYRAKR-TTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQ 266
            :.||||.::|||:: .|.||...:...|.::.||:.|.|.||.|:.|..::|:..||.:|. .|.
  Rat   133 FLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFF-YNW 196

  Fly   267 YITFGTALAAFYFPVTIMCF----LYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNH 327
            |.....:...|:.|...:.|    :|..|.|.|:.|
  Rat   197 YFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR----------------------------- 232

  Fly   328 ASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYT 392
                                                   :|
  Rat   233 ---------------------------------------LD------------------------ 234

  Fly   393 CFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMG 457
                                                                            |
  Rat   235 ----------------------------------------------------------------G 235

  Fly   458 GSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHN 522
            |..:|..||    .|..|:|.|.||                :.......|:|.....:.......
  Rat   236 GREAGPEPP----PDAQPSPPPAPP----------------SCWGCWPKGHGEAMPLHRYGVGEA 280

  Fly   523 GNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAA 587
            |.|...|..|
  Rat   281 GPGVEAGEAA------------------------------------------------------- 290

  Fly   588 NGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLP----SRDSEF 648
              .|||.|.|||||                    ||:::.    :|:..|.||..    |:.|..
  Rat   291 --LGGGSGGGAAAS--------------------PTSSSG----SSSRGTERPRSLKRGSKPSAS 329

  Fly   649 SLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQES 713
            |..|.:||.                                    |.:::..::.:.|::|
  Rat   330 SASLEKRMK------------------------------------MVSQSITQRFRLSRDK---- 354

  Fly   714 KAAKTLSAILLSFIITWTPYNILVLIKPLTTC-SDCIP 750
            |.||:|:.|:..|.:.|.||.:|::|:  ..| ..|||
  Rat   355 KVAKSLAIIVSIFGLCWAPYTLLMIIR--AACHGRCIP 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	52/124 (42%)
		7tm_1	121..>314	CDD:278431	69/197 (35%)
Hrh3	NP_001257495.1	7tm_1	51..>230	CDD:278431	67/179 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..259		12/132 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..336		21/130 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010