Protein Alignment mAChR-A and chrm1a

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_001332293.3
• Gene: chrm1a / 792708
• ZFINID: ZDB-GENE-090410-9
• Length: 442
• Species: Danio rerio
• Alignment Length: 689
• Identity: 211/689 - (30%)
• Similarity: 291/689 - (42%)
• Gaps: 271/689 - (39%)

  Fly   109 FVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLG 173
            |:...||.:|:.|||:|||||:::..|:|:|||||.|||:||..:|:|||.|:....:|..|.||
Zfish     4 FITVPLSLITITGNVLVMISFRVNPLLRTVSNYFLLSLAVADVILGSISMNLYTTYILLNGWTLG 68

  Fly   174 PIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPP 238
            .:.||.|||:||:||||||:|||.||.|||.||.||||||||||..||.:||..||.||.::|.|
Zfish    69 NLACDVWLAVDYVASNASVMNLLAISIDRYLSVMRPLTYRAKRTPKRAMIMISLAWTISFVIWAP 133

  Fly   239 WIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLP 303
            .|..|.||.|:|||.::||.|||: :...||||||:||||.||::|..||||::|||:||.:.|.
Zfish   134 AILFWQYIVGERTVQENECSIQFL-SEPVITFGTAIAAFYLPVSVMVALYWRVYRETEKRSQKLA 197

  Fly   304 NLQAGK----KDSSKRS--NSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYM 362
            .|.|.:    .::|:||  :||..|..|                      ||::    |.:...:
Zfish   198 GLMASQGGRTGNASQRSCQSSSRSNEDV----------------------RPQT----DQQQQQL 236

  Fly   363 TNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGY 427
            .|                  ....:..|:|      ....|.|...|        |:|:.|: .|
Zfish   237 RN------------------EPRPVCPSFT------HRTAACWKKQR--------EREDISN-SY 268

  Fly   428 ATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEM 492
            ||
Zfish   269 AT--------------------------------------------------------------- 270

  Fly   493 SAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVI 557
                                   ||:                                    |.:
Zfish   271 -----------------------NNH------------------------------------PQV 276

  Fly   558 NRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGP 622
            :.|:||: ..::.|     :|..|...:|||       ....|:.:.|.|.:...|:.     .|
Zfish   277 DFISSRT-DHNNKY-----IPLVGMDKSAAN-------KPHDATMNNSDQSESPNSLM-----NP 323

  Fly   623 TTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGV 687
            .||.|:|.|.:|                  |:|
Zfish   324 ATTQASALLLNA------------------GQR-------------------------------- 338

  Fly   688 GGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTE 752
                         .:|.::....:|.|||:|||||||:||:|||||||:||:.  |.|.:|:|..
Zfish   339 -------------SRKARTSSLIKEKKAARTLSAILLAFIVTWTPYNIMVLVS--TFCDNCVPER 388

  Fly   753 LWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKW 791
            ||...|.|||:|||:||:||||||..||.|:..:|.|:|
Zfish   389 LWKLGYWLCYVNSTVNPLCYALCNKHFRVTFRALLLCRW 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	73/123 (59%)
		7tm_1	121..>314	CDD:278431	110/196 (56%)
chrm1a	XP_001332293.3	7tm_4	7..>195	CDD:304433	110/188 (59%)
		7tm_1	16..408	CDD:278431	195/656 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I1022
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1990
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	1	1.000	-	-		FOG0001308
OrthoInspector	1	1.000	-	-		otm24829
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.070