DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and hrh1

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_001036196.1 Gene:hrh1 / 735302 ZFINID:ZDB-GENE-070531-3 Length:534 Species:Danio rerio


Alignment Length:777 Identity:171/777 - (22%)
Similarity:269/777 - (34%) Gaps:262/777 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 FKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQT 86
            |.|..||..|......||||.|.:              .:.|:.:.:|.   |..|.:.::.:..
Zfish     3 FLTTLTSCDTLERPMESTTTLTTA--------------NSQFKRIDNTT---LLIPSAPLHHHIN 50

  Fly    87 NGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADF 151
            |                 .|:|....:||.:||..|::|:.:.:.::.|.|:.|.::.||:|||.
Zfish    51 N-----------------AVLGIFLGMLSLLTVIMNLLVLFAVRKERTLHTVGNLYIVSLSIADL 98

  Fly   152 AIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKR 216
            .:||..|||..|..:...|.||.:||..||.:||:||.||:.:|.|:..|||.||..||.|...|
Zfish    99 IVGATVMPLNLVYLLEDQWKLGHVVCQFWLVMDYVASTASIFSLFILCLDRYRSVRHPLQYLKYR 163

  Fly   217 TTNRAAVMIGAAWGISLLLWPPWIYSWPYIEG--KRTVPKDECYIQFIETNQYITFG---TALAA 276
            |..||.::|.:||.:| :.|...|..|.....  |:|..:::|...|    :::|:.   ||:..
Zfish   164 TRGRATLLICSAWLLS-MTWTIPILGWRMFASVDKKTELENQCDTDF----RFVTWFKVLTAILN 223

  Fly   277 FYFPVTIMCFLYWRIWRETKKRQKDLPNLQAG---KKDSSKRSNSSDENTVVNHASGGLLAFAQV 338
            ||.|..:|...|.:|:...:...::..|. ||   |.|::        :|:.|   |..|...:.
Zfish   224 FYIPSFLMLVFYSQIFIAVRDHYREWENF-AGPALKTDAT--------DTLTN---GLQLQITKA 276

  Fly   339 GGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIA 403
                        ||....|.:.|..|.                             |.:.::.:.
Zfish   277 ------------SEKESLALNAYSQNE-----------------------------GLLDQYSLE 300

  Fly   404 WWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSI 468
            ..::.||::::...|.:............:...::.||                       |.|.
Zfish   301 QPYNSRENTEEMTSEPKRKMCYKKKAIFNLSKRMRKSV-----------------------PDSE 342

  Fly   469 L--LSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNG 531
            :  .||...|.....|..|::.||..:.....|..||:   :.|..:.|                
Zfish   343 ISFQSDDGETVAEGRPSLSLAFLQSENTAQPQTFINVS---DCNVLVPN---------------- 388

  Fly   532 AGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGP-- 594
                      :.||.    ..:.|.::..|         ||.::..|....|..|.|    .|  
Zfish   389 ----------SVGNI----CESAPTVDIHN---------YTAVLCTPPSPPSPWAEN----SPPL 426

  Fly   595 GAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHA 659
            .|..|..|..|.|..|..|.:.||                                         
Zfish   427 DASIALPAKQSWQKLCEQSKQSIH----------------------------------------- 450

  Fly   660 QHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILL 724
                                                          |...|:|.|||:.|..|:.
Zfish   451 ----------------------------------------------SMRIRKERKAARQLGFIIG 469

  Fly   725 SFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRI 786
            .|::.|.||.|..::..|  |..|:..:|..|...|.|||||:||..|.|||..|:|.:.:|
Zfish   470 VFMVCWIPYFITFMVMAL--CETCVHHDLHMFTIWLGYINSTLNPFIYPLCNENFKRVFKKI 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 69/199 (35%)
TM helix 1 106..132 CDD:320428 8/25 (32%)
TM helix 2 139..165 CDD:320428 12/25 (48%)
TM helix 3 177..207 CDD:320428 15/29 (52%)
TM helix 4 219..242 CDD:320428 8/22 (36%)
TM helix 5 265..294 CDD:320428 9/31 (29%)
7tm_GPCRs <707..783 CDD:475119 31/75 (41%)
TM helix 6 716..738 CDD:410628 8/21 (38%)
TM helix 7 751..776 CDD:410628 12/24 (50%)
hrh1NP_001036196.1 7tmA_Histamine_H1R 52..>243 CDD:320178 69/195 (35%)
TM helix 1 53..79 CDD:320178 8/25 (32%)
TM helix 2 86..112 CDD:320178 12/25 (48%)
TM helix 3 124..154 CDD:320178 15/29 (52%)
TM helix 4 166..187 CDD:320178 7/21 (33%)
TM helix 5 212..241 CDD:320178 9/28 (32%)
7tm_GPCRs <454..526 CDD:475119 31/73 (42%)
TM helix 6 461..483 CDD:410628 8/21 (38%)
TM helix 7 494..519 CDD:410628 12/24 (50%)

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