DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-A and HRH4

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_067637.2	Gene:	HRH4 / 59340	HGNCID:	17383	Length:	390	Species:	Homo sapiens

Alignment Length:	360	Identity:	100/360 - (27%)
Similarity:	158/360 - (43%)	Gaps:	88/360 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 TNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIAD 150
            ||.||..       ||::.|.:.|..::::...:.||.:|:::|.:||.|:..|:||..:|||:|
Human     4 TNSTINL-------SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISD 61

  Fly   151 FAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAK 215
            |.:|.||:||:...|:. .|..|..:|..||..|||...|||.|:::||:|||.||:..::||.:
Human    62 FFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQ 125

  Fly   216 RT-TNRAAVMIGAAWGISLLLWPPWIY---SWPYIEGKRTVPKD---ECYIQFIETNQYITFGTA 273
            .| ..:...::.|.|.::.|:..|.|.   ||          ||   ||...|. :..||...|:
Human   126 HTGVLKIVTLMVAVWVLAFLVNGPMILVSESW----------KDEGSECEPGFF-SEWYILAITS 179

  Fly   274 LAAFYFPVTIMCF----LYWRIW-RETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLL 333
            ...|..||.::.:    :||.:| |:...|.:..|.|.|            ..:.:..|:..|.|
Human   180 FLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTA------------VSSNICGHSFRGRL 232

  Fly   334 AFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHG-MHSRKSSI-------KSTNTIKKS 390
            :.           ||..|.|:.           :.:.:|. ...||||:       .::|||...
Human   233 SS-----------RRSLSASTE-----------VPASFHSERQRRKSSLMFSSRTKMNSNTIASK 275

  Fly   391 YTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDL 425
               .||..:            ||..|..|.|..:|
Human   276 ---MGSFSQ------------SDSVALHQREHVEL 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	47/124 (38%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	69/204 (34%)
HRH4	NP_067637.2	7tmA_Histamine_H4R	16..374	CDD:320422	94/341 (28%)
		TM helix 1	17..43	CDD:320422	5/25 (20%)
		TM helix 2	50..77	CDD:320422	13/26 (50%)
		TM helix 3	87..117	CDD:320422	16/29 (55%)
		TM helix 4	132..150	CDD:320422	3/17 (18%)
		TM helix 5	171..201	CDD:320422	8/29 (28%)
		TM helix 6	296..326	CDD:320422	100/360 (28%)
		TM helix 7	337..362	CDD:320422
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010