DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-A and Chrm5

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_059058.1	Gene:	Chrm5 / 53949	RGDID:	620027	Length:	531	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	230/719 - (31%)
Similarity:	322/719 - (44%)	Gaps:	208/719 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 YGNQT-NGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFS 145
            |...| |||........|:.|..::.:..|.|::|.:|:.|||:||||||::.||:|::||:|.|
  Rat     6 YNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLS 70

  Fly   146 LAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPL 210
            ||.||..||..||.|:....::|.|.||.:.||.||||||:||||||:|||:||||||||:||||
  Rat    71 LACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPL 135

  Fly   211 TYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALA 275
            |||||||..||.:|||.||.:|.:||.|.|..|.|:.||||||.|||.|||: :...||||||:|
  Rat   136 TYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFL-SEPTITFGTAIA 199

  Fly   276 AFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVV-NHASGGLLAFAQVG 339
            |||.||::|..||.||:|||:||.|||.:||.....:..:.....:.|:: :..|....:.||
  Rat   200 AFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQ-- 262

  Fly   340 GNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAW 404
                    |.|:::                      |..||.:||:|..|:........:|
  Rat   263 --------RERNQA----------------------SWSSSRRSTSTTGKTTQATDLSADW---- 293

  Fly   405 WHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSIL 469
                         |:.|                  .|:.|:|.....|
  Rat   294 -------------EKAE------------------QVTTCSSYPSSED----------------- 310

  Fly   470 LSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAIN-NNNNASHNGNGAVNGNGAG 533
              :..||..|      :.|:...|....|.....||.......:| ...|:.::
  Rat   311 --EAKPTTDP------VFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYD----------- 356

  Fly   534 NGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGA 598
                         |.:...:....:|:.|:..   ..|...:.:.:||  :...|.|
  Rat   357 -------------TPKYFLSPAAAHRLKSQKC---VAYKFRLVVKADG--TQETNNG-------- 395

  Fly   599 AASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDA 663
                       |. .:|::        ..:.|::...:|:.|.|:            :||..
  Rat   396 -----------CR-KVKIM--------PCSFPVSKDPSTKGPDPN------------LSHQM--- 425

  Fly   664 RLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFII 728
                                                  .|:|.....:|.|||:|||||||:|||
  Rat   426 --------------------------------------TKRKRMVLVKERKAAQTLSAILLAFII 452

  Fly   729 TWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHT 793
            |||||||:||:.  |.|..|:|..||...|.|||:||||||:||||||.|||:|:..:|.|:|..
  Rat   453 TWTPYNIMVLVS--TFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKK 515

  Fly   794 RNRE 797
            :..|
  Rat   516 KKVE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	77/123 (63%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	118/192 (61%)
Chrm5	NP_059058.1	7tm_4	39..>166	CDD:304433	78/126 (62%)
		7tm_1	46..255	CDD:278431	119/209 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..295		12/84 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1013
eggNOG	1	0.900	-	-		E1_KOG4220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1957
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	1	1.000	-	-		FOG0001308
OrthoInspector	1	1.000	-	-		otm45907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930