DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and 5-HT7

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_524599.1 Gene:5-HT7 / 43669 FlyBaseID:FBgn0004573 Length:564 Species:Drosophila melanogaster


Alignment Length:842 Identity:163/842 - (19%)
Similarity:257/842 - (30%) Gaps:389/842 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LALAAHGPPSILEPLFKTVTTSTTTTTTTTTS-------TTTTTASPAGYSPGYPGTTLLTALFE 64
            :|.|| |..::..||.:..|.|.|:....::|       :.::|.|.:|...|            
  Fly    46 IAYAA-GKATVPAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSG------------ 97

  Fly    65 NLTSTAASGLYDPYSGMYG----------------------NQTNGTIGFETKGP----RYSLAS 103
               |.:.||     ||.||                      ..:|.|:...:..|    .::...
  Fly    98 ---SGSGSG-----SGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGE 154

  Fly   104 MVVMG----FVAAILSTV---TVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLF 161
            .|:..    ||:.:|..|   ||.|||:|.|:..:.::|:...||.|.|||::|..:..:.||:.
  Fly   155 FVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMA 219

  Fly   162 AVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIG 226
            .:..:|..|..||::||.|::.|.|...||:|||..||.|||.::|:||.|..|||..|..:.:|
  Fly   220 LLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVG 284

  Fly   227 AAW-GISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWR 290
            ..| ..:.:..||.:......|.:...|  .|.:  .:...|..:.| |.:||.|:::|.|:|::
  Fly   285 IVWLAAACISLPPLLILGNEHEDEEGQP--ICTV--CQNFAYQIYAT-LGSFYIPLSVMLFVYYQ 344

  Fly   291 IWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSP 355
            |:|..::                                                          
  Fly   345 IFRAARR---------------------------------------------------------- 351

  Fly   356 DAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQE 420
                     :|::.                  |::                              
  Fly   352 ---------IVLEE------------------KRA------------------------------ 359

  Fly   421 EPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLAS 485
                         :|.||.:::..             ||.|..:.|          ||....|||
  Fly   360 -------------QTHLQQALNGT-------------GSPSAPQAP----------PLGHTELAS 388

  Fly   486 ISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRD 550
                                ||||.         .|:                   :.||     
  Fly   389 --------------------SGNGQ---------RHS-------------------SVGN----- 400

  Fly   551 SRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIK 615
                                           .|...:..||...|.||.|               
  Fly   401 -------------------------------TSLTYSTCGGLSSGGGALA--------------- 419

  Fly   616 MIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGG 680
                                                                            |
  Fly   420 ----------------------------------------------------------------G 420

  Fly   681 GAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTC 745
            ..:||||.|:..|:.:.:   .||...:..:|.||:.||..|:.:|.:.|.|:.||.||:|..|.
  Fly   421 HGSGGGVSGSTGLLGSPH---HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETM 482

  Fly   746 SDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRN---REGMVRGVY 804
            .  :|..|...|..|.|.||.:||:.||..|..||:.:..||..:..:.|   ||...:..|
  Fly   483 H--VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYYQDQY 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 67/202 (33%)
TM helix 1 106..132 CDD:320428 11/32 (34%)
TM helix 2 139..165 CDD:320428 9/25 (36%)
TM helix 3 177..207 CDD:320428 15/29 (52%)
TM helix 4 219..242 CDD:320428 5/23 (22%)
TM helix 5 265..294 CDD:320428 10/28 (36%)
7tm_GPCRs <707..783 CDD:475119 29/75 (39%)
TM helix 6 716..738 CDD:410628 8/21 (38%)
TM helix 7 751..776 CDD:410628 10/24 (42%)
5-HT7NP_524599.1 7tmA_5-HT7 163..518 CDD:320452 132/678 (19%)
TM helix 1 164..190 CDD:320452 11/25 (44%)
TM helix 2 197..223 CDD:320452 9/25 (36%)
TM helix 3 235..265 CDD:320452 15/29 (52%)
TM helix 4 277..299 CDD:320452 5/21 (24%)
TM helix 5 319..348 CDD:320452 10/29 (34%)
TM helix 6 447..477 CDD:320452 12/29 (41%)
TM helix 7 486..511 CDD:320452 10/24 (42%)

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