DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-A and CG13579

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001261169.1	Gene:	CG13579 / 37905	FlyBaseID:	FBgn0035010	Length:	716	Species:	Drosophila melanogaster

Alignment Length:	746	Identity:	147/746 - (19%)
Similarity:	236/746 - (31%)	Gaps:	215/746 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PRYS----LASMVVMGFVAAILSTVTVAG----NVMVMISFKIDKQ-----LQTISNYFLFSLAI 148
            ||||    :|.:.:...:.|:|..|...|    |.:|:  |.|:.:     :.....|.|.|||:
  Fly    22 PRYSGHNFIAHIGIAETIEAVLILVLTLGVIGANCLVI--FVINNRRYAAYIHQQPRYLLTSLAL 84

  Fly   149 ADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYR 213
            .|..||.:..|...:..:...||.|.|.|.....|....|..|.:.|:.::.|||.....|..|.
  Fly    85 NDLTIGLLITPFGLMPALFHCWPYGEIFCQIQALLRGALSQQSAVILVCMAVDRYMCALHPRRYY 149

  Fly   214 AKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQ--------FIETNQYITF 270
            ...:......::...|.|||.::           |...:||...:..        |.....|...
  Fly   150 QHSSKKGCVAILSLTWIISLTVF-----------GFLVLPKGYYFNNTGLMACEPFYSKPSYRIL 203

  Fly   271 GTALAAFYFPVT-IMCFLYWRIWRETKKRQKD--LPNLQAGKKDSSKRSNSSDENTVV-----NH 327
            .|  .|.|||.| ::.:.|...:..::.|..|  :|...|..........::.:...:     :|
  Fly   204 ST--CALYFPTTMVLMYCYGSSFHMSRFRLNDPTMPLTAAAHHPHPHPHPTAAQQLQMHQHQQHH 266

  Fly   328 ASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVY------------MTNMVIDSGYHGMHSRKSS 380
            ...|:.:....|.:.|     |...|.|:..:.:            ..:|.:..|..||.:
  Fly   267 QQAGMHSHLYHGHSHH-----PSHPSHPNHPNHHGHPHHHGPPVMGHLSMAMSMGLAGMPN---- 322

  Fly   381 IKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCT 445
              .||.|.|...   .|:|          ::|............||:...||..| :|..|:.||
  Fly   323 --MTNKITKKIV---PIQE----------KNSSGSTSRSMAAISLGFIVMVTPWT-IQEIVTACT 371

  Fly   446 S------MNVMRDNYSMGGSV----------SGVRPPS-----------------------ILLS 471
            .      ::.:....::..|:          |..|..|                       |..:
  Fly   372 GSKLPPFLDFLVTWTALSNSLWNPFMYWLLNSDFRRMSRQLMPNKCFPHEDTPEHKSGCCHINAN 436

  Fly   472 DVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGS 536
            |...|.||.||....|:               ...|.|.|....::....:|.|..:..|   ||
  Fly   437 DFEITTLPIPPEPPSSR---------------PPGGAGGGGGGPSSGGPSSGGGVASSIG---GS 483

  Fly   537 GIGL------------------GTTGNATHRD------SRTLPVINRINSRSVSQDSVYTILIRL 577
            .:|:                  ||.|...|..      |.|.|.|..::.:...:     ||.|.
  Fly   484 VLGICGRSRTNSLSRSASQYIRGTMGGGVHNHQATETFSTTRPDIEGLSEKYWGE-----ILERT 543

  Fly   578 PSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSI-------------KMIHEDGPTTTAAAA 629
            .|.| :.||                   ||....|.:             :..|:...|:.:.|:
  Fly   544 VSSG-NLNA-------------------MQKHLPPHLPYAHHLVHQIHQPQQHHQQQTTSFSKAS 588

  Fly   630 PL-----ASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVI---PKQLGKAGGGAAGGG 686
            .|     .|.|||...|    .:||....:...|..||.....:|..   .:..||...|.:...
  Fly   589 DLQLNLNLSQAATAAEL----GKFSNSEPKLCEHLFHDVNCAKSKAANGDGESSGKLACGRSIPD 649

  Fly   687 VGGAHALMNARN---AAKKKKKSQEKRQESK 714
            :..|..::.|:|   |.:.|.......|::|
  Fly   650 IXYAEDVILAKNQLLARQAKCSHHPLHQQAK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	33/132 (25%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	48/212 (23%)
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	26/98 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840