Protein Alignment mAChR-A and chrm2a

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_840086.1
• Gene: chrm2a / 352938
• ZFINID: ZDB-GENE-030314-1
• Length: 495
• Species: Danio rerio
• Alignment Length: 719
• Identity: 222/719 - (30%)
• Similarity: 305/719 - (42%)
• Gaps: 235/719 - (32%)

  Fly    76 DPYSGMYGNQTNGTIGFET--KGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTI 138
            |..:..:.|.::|....||  :.| |....:|.:..||..||.|||.||::||:|.|:::.|||:
Zfish     2 DTINFTFWNASDGNETMETADESP-YKTVEVVFIVLVAGSLSLVTVIGNILVMLSIKVNRSLQTV 65

  Fly   139 SNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRY 203
            :||||||||.||..||..||.|:.|..::|||||||:|||.||||||:.|||||:||||||||||
Zfish    66 NNYFLFSLACADLIIGLCSMNLYTVYIVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRY 130

  Fly   204 FSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYI 268
            |.||:||:|...|||..|.:||.|||.:|.:||.|.|..|.:|.|.||||:.||||||. :|..:
Zfish   131 FCVTKPLSYPVNRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEKECYIQFF-SNAAV 194

  Fly   269 TFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLL 333
            |||||:||||.||.||..|||::.|.:|.|.         |||:.|.|
Zfish   195 TFGTAIAAFYLPVIIMMVLYWQVSRASKSRV---------KKDNRKPS----------------- 233

  Fly   334 AFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIK 398
                 |||                         :|            :.|:|.|:::
Zfish   234 -----GGN-------------------------LD------------VASSNQIREN-------- 248

  Fly   399 EWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGV 463
                   .:.:..:::...|:   :|.| .|.:|.:|..|            .|.....|..
Zfish   249 -------SANKPTNNNLTAEE---TDRG-QTQLTDDTINQ------------HDAKLQNGKA--- 287

  Fly   464 RPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVN 528
                           |........:..:.:.:.|....:.|.|.:|:||:.|...     ..|..
Zfish   288 ---------------PSTASGEAEEAGQANCIPAEEKESSNDSTSGSGAVTNQKE-----EAAPP 332

  Fly   529 GNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGG 593
            .:.|.|               ||:|                              |.......||
Zfish   333 SSAAAN---------------DSQT------------------------------STRHRAKAGG 352

  Fly   594 PGAGAAASASLSMQGDC-APSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMS 657
            .........:.|.:||| |||...:.                              .:|...|.:
Zfish   353 SKLTCIKIITKSPKGDCYAPSNATVE------------------------------IVPAVERQN 387

  Fly   658 HAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAI 722
            |.                              |..::.......||||:...| |.|..:|:.||
Zfish   388 HV------------------------------ARKIVKMTKQPPKKKKAPSSR-EKKVTRTIMAI 421

  Fly   723 LLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
            |::|:.||||||::|||...  ||.|||..:|...|.||||||||||.||||||.||::|:.::|
Zfish   422 LVAFVATWTPYNVMVLINAF--CSSCIPNTVWTIGYWLCYINSTINPACYALCNITFKKTFKQLL 484

  Fly   788 TCKW 791
            .|::
Zfish   485 LCQY 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	78/123 (63%)
		7tm_1	121..>314	CDD:278431	112/192 (58%)
chrm2a	NP_840086.1	7tm_4	40..>173	CDD:304433	82/132 (62%)
		7tm_1	48..>231	CDD:278431	112/192 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24829
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020