DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mAChR-A and HRH2

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_001354640.1 Gene:HRH2 / 3274 HGNCID:5183 Length:422 Species:Homo sapiens


Alignment Length:440 Identity:116/440 - (26%)
Similarity:187/440 - (42%) Gaps:86/440 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVT 164
            |.|..:.:..|.|:|..:||||||:|.::..::::|:.::|.|:.||||.|..:|.:.:|..|:.
Human    14 STACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78

  Fly   165 TILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAW 229
            .:...|..|.:.|:.:.:||.:...||:|||.:||.|||.:|..||.|....|..|.|:.:...|
Human    79 QLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIW 143

  Fly   230 GISLLLWPPWIY-SW----PYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYW 289
            .||:.|....|: .|    ...:|..|..|  |.:|   .|:.......|..||.|:.|||..|:
Human   144 VISITLSFLSIHLGWNSRNETSKGNHTTSK--CKVQ---VNEVYGLVDGLVTFYLPLLIMCITYY 203

  Fly   290 RIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGG---------LLAFAQVGGNDHDT 345
            ||::..:.:.|.:.::.:.|..:.:...:    ||...|..|         ..||...|....|.
Human   204 RIFKVARDQAKRINHISSWKAATIREHKA----TVTLAAVMGAFIICWFPYFTAFVYRGLRGDDA 264

  Fly   346 ----------W-RRPRSESSPDAESVYMT-NMVIDSGYHGM--------HSRKSSIKSTNTIKKS 390
                      | ....|..:|   .:|.. |....:||..:        :|.|:|::| |..:.|
Human   265 INEVLEAIVLWLGYANSALNP---ILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRS-NASQLS 325

  Fly   391 YTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSR-----CT--SMN 448
                              |..|.:...::|:|..|...:...:..| |.:..|     ||  |.|
Human   326 ------------------RTQSREPRQQEEKPLKLQVWSGTEVTAP-QGATDRKPALSCTTCSSN 371

  Fly   449 VMRDNYSMGGSVSGVR-------PPSILLS--DVSPTPLPRPPLASISQL 489
            ::    |...|:.|:|       .||..||  .:|..|..|||..::..|
Human   372 LL----SCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQKAVRTL 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 65/199 (33%)
TM helix 1 106..132 CDD:320428 10/25 (40%)
TM helix 2 139..165 CDD:320428 10/25 (40%)
TM helix 3 177..207 CDD:320428 13/29 (45%)
TM helix 4 219..242 CDD:320428 7/23 (30%)
TM helix 5 265..294 CDD:320428 11/28 (39%)
7tm_GPCRs <707..783 CDD:475119
TM helix 6 716..738 CDD:410628
TM helix 7 751..776 CDD:410628
HRH2NP_001354640.1 7tmA_Histamine_H2R 19..299 CDD:320179 80/291 (27%)
TM helix 1 20..46 CDD:320179 10/25 (40%)
TM helix 2 53..80 CDD:320179 10/26 (38%)
TM helix 3 91..121 CDD:320179 13/29 (45%)
TM helix 4 133..153 CDD:320179 6/19 (32%)
TM helix 5 179..209 CDD:320179 11/29 (38%)
TM helix 6 227..257 CDD:320179 6/33 (18%)
TM helix 7 267..292 CDD:320179 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340 7/42 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.