DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-A and HRH1

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_000852.1	Gene:	HRH1 / 3269	HGNCID:	5182	Length:	487	Species:	Homo sapiens

Alignment Length:	710	Identity:	162/710 - (22%)
Similarity:	262/710 - (36%)	Gaps:	247/710 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KGPRYSLASMVVMGFVAAILST---VTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAI 156
            :|.:.::||..:|..| .:|||   |||..|::|:.:.:.:::|.|:.|.::.||::||..:||:
Human    16 EGNKTTMASPQLMPLV-VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAV 79

  Fly   157 SMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRA 221
            .||:..:..::..|.||..:|..||::||:||.||:.::.|:..|||.||.:||.|...||..||
Human    80 VMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRA 144

  Fly   222 AVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPK-DECYIQFIETNQYITFGTALAAFYFPVTIMC 285
            :..|..||.:| .||...|..|.:...:.:|.: |:|...|.:...:... ||:..||.|..:|.
Human   145 SATILGAWFLS-FLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVM-TAIINFYLPTLLML 207

  Fly   286 FLYWRIWRETKK--RQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRR 348
            :.|.:|::..::  :.::|.|          ||               |.:|:::.       .|
Human   208 WFYAKIYKAVRQHCQHRELIN----------RS---------------LPSFSEIK-------LR 240

  Fly   349 PRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSD 413
            |   .:|..::                            ||.    |....|.:.
Human   241 P---ENPKGDA----------------------------KKP----GKESPWEVL---------- 260

  Fly   414 DFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPL 478
                 :.:|.|.|                              ||||  ::.||     .:|..:
Human   261 -----KRKPKDAG------------------------------GGSV--LKSPS-----QTPKEM 283

  Fly   479 PRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTT 543
            ..|.:.|....:|:..:.....                        ..|:...|..||
Human   284 KSPVVFSQEDDREVDKLYCFPL------------------------DIVHMQAAAEGS------- 317

  Fly   544 GNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQG 608
                   ||....:||.:.:           ::....|.:::           ||:..:...|.|
Human   318 -------SRDYVAVNRSHGQ-----------LKTDEQGLNTH-----------GASEISEDQMLG 353

  Fly   609 DCAPSIKMIHEDGPTTTAAA---APLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKV 670
            |   |......|..|||..|   ..|.|.:.|..      ........|..||::.
Human   354 D---SQSFSRTDSDTTTETAPGKGKLRSGSNTGL------DYIKFTWKRLRSHSRQ--------- 400

  Fly   671 IPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNI 735
                           .|.|.|  ||               :|.||||.|..|:.:||:.|.||.|
Human   401 ---------------YVSGLH--MN---------------RERKAAKQLGFIMAAFILCWIPYFI 433

  Fly   736 LVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRN 795
            ..::  :..|.:|....|..|...|.|||||:||:.|.|||..|::|:.|||    |.|:
Human   434 FFMV--IAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL----HIRS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	47/123 (38%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	60/195 (31%)
HRH1	NP_000852.1	7tmA_Histamine_H1R	28..479	CDD:320178	153/684 (22%)
		TM helix 1	30..54	CDD:320178	9/24 (38%)
		TM helix 2	63..85	CDD:320178	9/21 (43%)
		TM helix 3	101..123	CDD:320178	9/21 (43%)
		Important for agonist binding	107..112		3/4 (75%)
		TM helix 4	146..162	CDD:320178	6/16 (38%)
		TM helix 5	188..211	CDD:320178	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..291		18/146 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..379		10/36 (28%)
		TM helix 6	414..436	CDD:320178	10/21 (48%)
		Important for agonist binding	424..428		2/3 (67%)
		TM helix 7	447..472	CDD:320178	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820