DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and HRH1

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_000852.1 Gene:HRH1 / 3269 HGNCID:5182 Length:487 Species:Homo sapiens


Alignment Length:710 Identity:162/710 - (22%)
Similarity:262/710 - (36%) Gaps:247/710 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 KGPRYSLASMVVMGFVAAILST---VTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAI 156
            :|.:.::||..:|..| .:|||   |||..|::|:.:.:.:::|.|:.|.::.||::||..:||:
Human    16 EGNKTTMASPQLMPLV-VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAV 79

  Fly   157 SMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRA 221
            .||:..:..::..|.||..:|..||::||:||.||:.::.|:..|||.||.:||.|...||..||
Human    80 VMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRA 144

  Fly   222 AVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPK-DECYIQFIETNQYITFGTALAAFYFPVTIMC 285
            :..|..||.:| .||...|..|.:...:.:|.: |:|...|.:...:... ||:..||.|..:|.
Human   145 SATILGAWFLS-FLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVM-TAIINFYLPTLLML 207

  Fly   286 FLYWRIWRETKK--RQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRR 348
            :.|.:|::..::  :.::|.|          ||               |.:|:::.       .|
Human   208 WFYAKIYKAVRQHCQHRELIN----------RS---------------LPSFSEIK-------LR 240

  Fly   349 PRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSD 413
            |   .:|..::                            ||.    |....|.:.          
Human   241 P---ENPKGDA----------------------------KKP----GKESPWEVL---------- 260

  Fly   414 DFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPL 478
                 :.:|.|.|                              ||||  ::.||     .:|..:
Human   261 -----KRKPKDAG------------------------------GGSV--LKSPS-----QTPKEM 283

  Fly   479 PRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTT 543
            ..|.:.|....:|:..:.....                        ..|:...|..||       
Human   284 KSPVVFSQEDDREVDKLYCFPL------------------------DIVHMQAAAEGS------- 317

  Fly   544 GNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQG 608
                   ||....:||.:.:           ::....|.:::           ||:..:...|.|
Human   318 -------SRDYVAVNRSHGQ-----------LKTDEQGLNTH-----------GASEISEDQMLG 353

  Fly   609 DCAPSIKMIHEDGPTTTAAA---APLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKV 670
            |   |......|..|||..|   ..|.|.:.|..      ........|..||::.         
Human   354 D---SQSFSRTDSDTTTETAPGKGKLRSGSNTGL------DYIKFTWKRLRSHSRQ--------- 400

  Fly   671 IPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNI 735
                           .|.|.|  ||               :|.||||.|..|:.:||:.|.||.|
Human   401 ---------------YVSGLH--MN---------------RERKAAKQLGFIMAAFILCWIPYFI 433

  Fly   736 LVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRN 795
            ..::  :..|.:|....|..|...|.|||||:||:.|.|||..|::|:.|||    |.|:
Human   434 FFMV--IAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL----HIRS 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 66/200 (33%)
TM helix 1 106..132 CDD:320428 10/28 (36%)
TM helix 2 139..165 CDD:320428 9/25 (36%)
TM helix 3 177..207 CDD:320428 14/29 (48%)
TM helix 4 219..242 CDD:320428 9/22 (41%)
TM helix 5 265..294 CDD:320428 8/28 (29%)
7tm_GPCRs <707..783 CDD:475119 30/75 (40%)
TM helix 6 716..738 CDD:410628 10/21 (48%)
TM helix 7 751..776 CDD:410628 12/24 (50%)
HRH1NP_000852.1 7tmA_Histamine_H1R 28..479 CDD:320178 153/684 (22%)
TM helix 1 29..55 CDD:320178 9/26 (35%)
TM helix 2 62..88 CDD:320178 9/25 (36%)
TM helix 3 100..130 CDD:320178 14/29 (48%)
Important for agonist binding. /evidence=ECO:0000269|PubMed:21697825 107..112 3/4 (75%)
TM helix 4 142..163 CDD:320178 8/21 (38%)
TM helix 5 187..323 CDD:320178 40/293 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..291 18/146 (12%)
TM helix 6 325..438 CDD:320178 38/186 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..379 10/36 (28%)
Important for agonist binding. /evidence=ECO:0000269|PubMed:21697825 424..428 2/3 (67%)
TM helix 7 447..472 CDD:320178 12/24 (50%)

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