Protein Alignment mAChR-A and Drd4

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_006230583.1
• Gene: Drd4 / 25432
• RGDID: 2522
• Length: 389
• Species: Rattus norvegicus
• Alignment Length: 733
• Identity: 130/733 - (17%)
• Similarity: 213/733 - (29%)
• Gaps: 360/733 - (49%)

  Fly    65 NLTSTAASGLYDPYSGMYGNQTNGT---IGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVM 126
            |.::|...||   .:|. |.::.||   :|....|....:..::::|.|        :|||.:|.
  Rat     3 NSSATGDGGL---LAGR-GPESLGTGTGLGGAGAGAAALVGGVLLIGMV--------LAGNSLVC 55

  Fly   127 ISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLALDYLASNA 190
            :|...::.|||.:|||:.|||.||..:..:.:|||..:.:. |.|.|.|.:|||.:|:|.:...|
  Rat    56 VSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTA 120

  Fly   191 SVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKD 255
            |:.||..||.||:.:||.||.|..:....  .::|.|.|.:|..:      :.|.:.|...||..
  Rat   121 SIFNLCAISVDRFVAVTVPLRYNQQGQCQ--LLLIAATWLLSAAV------AAPVVCGLNDVPGR 177

  Fly   256 ECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSD 320
            :..:..:|...|:.: :::.:|:.|..:|..|||..:|..::
  Rat   178 DPTVCCLEDRDYVVY-SSICSFFLPCPLMLLLYWATFRGLRR----------------------- 218

  Fly   321 ENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTN 385
                                     |...|                    :..:|||
  Rat   219 -------------------------WEAAR--------------------HTKLHSR-------- 230

  Fly   386 TIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVM 450
                                            ....||  |...||:  .|.|..
  Rat   231 --------------------------------APRRPS--GPGPPVS--DPTQGP---------- 249

  Fly   451 RDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINN 515
                              |.||..|   |.|.|
  Rat   250 ------------------LFSDCPP---PSPSL-------------------------------- 261

  Fly   516 NNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSD 580
                                                ||.|.   ::||..|..|
  Rat   262 ------------------------------------RTSPT---VSSRPESDLS----------- 276

  Fly   581 GASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRD 645
                                      |..|:|               ...|..||..:.|.||
  Rat   277 --------------------------QSPCSP---------------GCLLPDAALAQPPAPS-- 298

  Fly   646 SEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKR 710
                                                                  :::|:.::...
  Rat   299 ------------------------------------------------------SRRKRGAKITG 309

  Fly   711 QESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC------IPTELWDFFYALCYINSTINP 769
            :|.||.:.|..::.:|::.|||:.::.:.:.|  |..|      :....|     |.|:||.:||
  Rat   310 RERKAMRVLPVVVGAFLMCWTPFFVVHITRAL--CPACFVSPRLVSAVTW-----LGYVNSALNP 367

  Fly   770 MCYALCNATFRRTYVRIL 787
            :.|.:.||.||..:.:.|
  Rat   368 IIYTIFNAEFRSVFRKTL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	60/195 (31%)
		TM helix 1	106..132	CDD:320428	7/25 (28%)
		TM helix 2	139..165	CDD:320428	11/25 (44%)
		TM helix 3	177..207	CDD:320428	13/29 (45%)
		TM helix 4	219..242	CDD:320428	4/22 (18%)
		TM helix 5	265..294	CDD:320428	7/28 (25%)
		7tm_GPCRs	<707..783	CDD:475119	23/81 (28%)
		TM helix 6	716..738	CDD:410628	5/21 (24%)
		TM helix 7	751..776	CDD:410628	8/24 (33%)
Drd4	XP_006230583.1	7tm_GPCRs	44..381	CDD:475119	119/682 (17%)
		TM helix 2	69..91	CDD:410628	10/21 (48%)
		TM helix 3	108..130	CDD:410628	9/21 (43%)
		TM helix 4	151..167	CDD:410628	4/21 (19%)
		TM helix 5	187..210	CDD:410628	5/23 (22%)
		TM helix 6	315..337	CDD:410628	5/21 (24%)
		TM helix 7	349..374	CDD:410628	8/29 (28%)