DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and Hrh1

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_058714.2 Gene:Hrh1 / 24448 RGDID:2830 Length:486 Species:Rattus norvegicus


Alignment Length:717 Identity:155/717 - (21%)
Similarity:249/717 - (34%) Gaps:243/717 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 NGTIGFETK---GPRYSLASMVVMGFVAAI--LSTVTVAGNVMVMISFKIDKQLQTISNYFLFSL 146
            |.:..||.|   |.|.::||..::..|..:  :|.|||..|::|:.:...:::|.|:.|.::.||
  Rat     5 NTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSL 69

  Fly   147 AIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLT 211
            ::||..:||:.||:..:..|:..|.||..:|..||::||:||.||:.::.|:..|||.||.:||.
  Rat    70 SVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLR 134

  Fly   212 YRAKRTTNRAAVMIGAAWGISLLLWPPWIYSW-PYIEGKRTVPKDECYIQFIETNQYITFGTALA 275
            |...||..||:..|..||..| .||...|..| .::.....:.:|:|...|.... :....||:.
  Rat   135 YLRYRTKTRASATILGAWFFS-FLWVIPILGWHHFMPPAPELREDKCETDFYNVT-WFKIMTAII 197

  Fly   276 AFYFPVTIMCFLYWRIWRETKK--RQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQV 338
            .||.|..:|.:.|.:|::..::  :.:.|.|                         |.|.:|:::
  Rat   198 NFYLPTLLMLWFYVKIYKAVRRHCQHRQLTN-------------------------GSLPSFSEL 237

  Fly   339 GGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIA 403
            .....||   ......|..||.:           |:..|.|...|....:||             
  Rat   238 KLRSDDT---KEGAKKPGRESPW-----------GVLKRPSRDPSVGLDQKS------------- 275

  Fly   404 WWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSI 468
                          ..|:|.   ..:|.......:.....|..:::|:......|.|.|      
  Rat   276 --------------TSEDPK---MTSPTVFSQEGERETRPCFRLDIMQKQSMAEGDVRG------ 317

  Fly   469 LLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAG 533
              |..:...|.:|.:                                                  
  Rat   318 --SKANDQALSQPKM-------------------------------------------------- 330

  Fly   534 NGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGA 598
                            |.::|....||:..|..|..|                            
  Rat   331 ----------------DEQSLNTCRRISETSEDQTLV---------------------------- 351

  Fly   599 AASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDA 663
             ...|.|...|...||    |.||                              ||..|.:..::
  Rat   352 -DQQSFSRTTDSDTSI----EPGP------------------------------GRVKSRSGSNS 381

  Fly   664 RLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFII 728
            .|...|:..|:|                     |:.:::........:|.||||.|..|:.:||:
  Rat   382 GLDYIKITWKRL---------------------RSHSRQYVSGLHLNRERKAAKQLGFIMAAFIL 425

  Fly   729 TWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHT 793
            .|.||.|..::  :..|..|....:..|...|.|||||:||:.|.|||..|::|:.:||    |.
  Rat   426 CWIPYFIFFMV--IAFCKSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKIL----HI 484

  Fly   794 RN 795
            |:
  Rat   485 RS 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 63/199 (32%)
TM helix 1 106..132 CDD:320428 7/27 (26%)
TM helix 2 139..165 CDD:320428 9/25 (36%)
TM helix 3 177..207 CDD:320428 14/29 (48%)
TM helix 4 219..242 CDD:320428 9/22 (41%)
TM helix 5 265..294 CDD:320428 8/28 (29%)
7tm_GPCRs <707..783 CDD:475119 29/75 (39%)
TM helix 6 716..738 CDD:410628 10/21 (48%)
TM helix 7 751..776 CDD:410628 11/24 (46%)
Hrh1NP_058714.2 7tmA_Histamine_H1R 29..478 CDD:320178 142/679 (21%)
TM helix 1 29..55 CDD:320178 7/25 (28%)
TM helix 2 62..88 CDD:320178 9/25 (36%)
TM helix 3 100..130 CDD:320178 14/29 (48%)
Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367 107..112 3/4 (75%)
TM helix 4 142..163 CDD:320178 8/21 (38%)
TM helix 5 187..216 CDD:320178 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..295 14/97 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..379 24/205 (12%)
TM helix 6 407..437 CDD:320178 13/31 (42%)
Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367 423..427 2/3 (67%)
TM helix 7 446..471 CDD:320178 11/24 (46%)

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