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Protein Alignment mAChR-A and Chrm2

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_987076.2	Gene:	Chrm2 / 243764	MGIID:	88397	Length:	466	Species:	Mus musculus

Alignment Length:	733	Identity:	222/733 - (30%)
Similarity:	291/733 - (39%)	Gaps:	295/733 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NQTNGT-IGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLA 147
            |.||.: .|.....| |....:|.:..||..||.||:.||::||:|.|:::.|||::||||||||
Mouse     3 NSTNSSNNGLAITSP-YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLA 66

  Fly   148 IADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTY 212
            .||..||..||.|:.:.|::|||||||:|||.||||||:.|||||:|||||||||||.||:||||
Mouse    67 CADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY 131

  Fly   213 RAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAF 277
            ..||||..|.:||.|||.:|.:||.|.|..|.:|.|.|||...||||||. :|..:|||||:|||
Mouse   132 PVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF-SNAAVTFGTAIAAF 195

  Fly   278 YFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGND 342
            |.||.||..|||.|.|.:|.|
Mouse   196 YLPVIIMTVLYWHISRASKSR-------------------------------------------- 216

  Fly   343 HDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHS 407
                                                        |||
Mouse   217 --------------------------------------------IKK------------------ 219

  Fly   408 GREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSG--VRPPSILL 470
                      |::|        ||..:.|:..|:                  |.|  |:|
Mouse   220 ----------EKKE--------PVANQDPVSPSL------------------VQGRIVKP----- 243

  Fly   471 SDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNG 535
                                                         |||....|:|.:..|...||
Mouse   244 ---------------------------------------------NNNNMPGGDGGLEHNKIQNG 263

  Fly   536 SGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAA 600
                                                    :.|.||.:.|...|
Mouse   264 ----------------------------------------KAPRDGGTENCVQG----------- 277

  Fly   601 SASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSL---PLGRRMSHAQHD 662
                        ..|....|..:.:|.|:.:            ||.|.:.   .:...:.|::.|
Mouse   278 ------------EEKESSNDSTSVSAVASNM------------RDDEITQDENTVSTSLGHSKDD 318

  Fly   663 -ARLLNAKVIPK-QLGKAGG---------GAAGGGVGGAHALMNARNAAKKKKKSQEKR----QE 712
             :|....|::.| |.|.|..         |::|.. |.....:.||...|..|:..:|:    :|
Mouse   319 NSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQN-GDEKQNIVARKIVKMTKQPAKKKPPPSRE 382

  Fly   713 SKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNA 777
            .|..:|:.||||:|||||.|||::|||.  |.|:.|||..:|...|.||||||||||.|||||||
Mouse   383 KKVTRTILAILLAFIITWAPYNVMVLIN--TFCAPCIPNTVWTIGYWLCYINSTINPACYALCNA 445

  Fly   778 TFRRTYVRILTCKWHTRN 795
            ||::|:..:|.|  |.:|
Mouse   446 TFKKTFKHLLMC--HYKN 461

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.