DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and Chrm5

DIOPT Version :9

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_991352.2 Gene:Chrm5 / 213788 MGIID:109248 Length:532 Species:Mus musculus


Alignment Length:731 Identity:230/731 - (31%)
Similarity:307/731 - (41%) Gaps:231/731 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 YGNQT--NGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLF 144
            |.|:|  |||........|:.|..::.:..|.|::|.:|:.|||:||||||::.||:|::||:|.
Mouse     6 YHNETTVNGTPVNHQALERHGLWEVITIAAVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLL 70

  Fly   145 SLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRP 209
            |||.||..||..||.|:....::|.|.||.:.||.||||||:||||||:|||:||||||||:|||
Mouse    71 SLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRP 135

  Fly   210 LTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTAL 274
            ||||||||..||.:|||.||.:|.:||.|.|..|.|:.||||||.|||.|||: :...||||||:
Mouse   136 LTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFL-SEPTITFGTAI 199

  Fly   275 AAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVV-NHASGGLLAFAQV 338
            ||||.||::|..||.||:|||:||.|||.:||.....:..:.......|:: :..|....:.||.
Mouse   200 AAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEVKKRKPAHRTLLRSFFSCPRPSLAQR 264

  Fly   339 GGNDHDTWRRPRSESSPDAESVYMTNMVID-------SGYHGMHSRKSSIKSTNTIKKSYTCFGS 396
            ..| ..:|...|..:|...:....|::..|       :......|.:...|:|........|...
Mouse   265 VRN-QASWSSSRRSTSTTGKPTQATDLSADWEKAEQVTNCSSCPSSEDEAKATTDPVFQVVCKNE 328

  Fly   397 IKEWCIAWWHSGR-----EDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSM 456
            .||      ..|:     |..:.|...:.|.:|  |.||....:|  .:..|..|...:...:.:
Mouse   329 AKE------SPGKEFNTQETKETFVSPRTENND--YDTPKYFLSP--GAAHRLKSQKCVAYKFRL 383

  Fly   457 GGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASH 521
                                                 .|.|..|...|                 
Mouse   384 -------------------------------------VVKADGTQETN----------------- 394

  Fly   522 NGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNA 586
                    ||.                |..:.:|.     |..||:|                  
Mouse   395 --------NGC----------------RKVKIMPC-----SFPVSKD------------------ 412

  Fly   587 ANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLP 651
                                     ||.|                                   .
Mouse   413 -------------------------PSTK-----------------------------------G 417

  Fly   652 LGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAA 716
            |...:||..                                         .|:|.....:|.|||
Mouse   418 LDPHLSHQM-----------------------------------------TKRKRMVLVKERKAA 441

  Fly   717 KTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRR 781
            :|||||||:||||||||||:||:.  |.|..|:|..||...|.|||:||||||:||||||.|||:
Mouse   442 QTLSAILLAFIITWTPYNIMVLVS--TFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRK 504

  Fly   782 TYVRILTCKWHTRNRE 797
            |:..:|.|:|..:..|
Mouse   505 TFKLLLLCRWKKKKVE 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tm_4 117..>241 CDD:304433 77/123 (63%)
7tm_1 121..>314 CDD:278431 118/192 (61%)
Chrm5NP_991352.2 7tmA_mAChR_M5 31..>225 CDD:320427 117/194 (60%)
TM helix 1 32..58 CDD:320427 13/25 (52%)
TM helix 2 65..91 CDD:320427 13/25 (52%)
TM helix 3 103..133 CDD:320427 25/29 (86%)
TM helix 4 145..168 CDD:320427 12/22 (55%)
TM helix 5 190..219 CDD:320427 17/28 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..290 5/25 (20%)
7tm_GPCRs <435..514 CDD:391938 51/80 (64%)
TM helix 6 438..463 CDD:341315 20/24 (83%)
TM helix 7 474..499 CDD:341315 16/24 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 346 1.000 Domainoid score I1044
eggNOG 1 0.900 - - E1_KOG4220
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 384 1.000 Inparanoid score I2017
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001308
OrthoInspector 1 1.000 - - otm43823
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2382
SonicParanoid 1 1.000 - - X324
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.950

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