Protein Alignment mAChR-A and DRD4

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_000788.2
• Gene: DRD4 / 1815
• HGNCID: 3025
• Length: 419
• Species: Homo sapiens
• Alignment Length: 727
• Identity: 131/727 - (18%)
• Similarity: 216/727 - (29%)
• Gaps: 318/727 - (43%)

  Fly    65 NLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISF 129
            |.::..|.||........|.....:.|...:|....:..::::|.|        :|||.:|.:|.
Human     3 NRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAV--------LAGNSLVCVSV 59

  Fly   130 KIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLALDYLASNASVL 193
            ..::.|||.:|.|:.|||.||..:..:.:|||..:.:. |.|.|.|.:||..:|:|.:...||:.
Human    60 ATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIF 124

  Fly   194 NLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECY 258
            ||..||.||:.:|..||.|..:..:.|..::|||.|.:|..:..|.:.....:.|     :|...
Human   125 NLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRG-----RDPAV 184

  Fly   259 IQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENT 323
            .: :|...|:.: :::.:|:.|..:|..|||..:|..::
Human   185 CR-LEDRDYVVY-SSVCSFFLPCPLMLLLYWATFRGLQR-------------------------- 221

  Fly   324 VVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIK 388
                                  |...|.                 :..||...|:.
Human   222 ----------------------WEVARR-----------------AKLHGRAPRRP--------- 238

  Fly   389 KSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDN 453
                                                                             
Human   239 ----------------------------------------------------------------- 238

  Fly   454 YSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNN 518
                   ||..||       |||| |.|
Human   239 -------SGPGPP-------SPTP-PAP------------------------------------- 251

  Fly   519 ASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGAS 583
                                                                     |||.|...
Human   252 ---------------------------------------------------------RLPQDPCG 259

  Fly   584 SNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHED--GPTTTAAAAPLASAAATRRPLPSRDS 646
            .:.|....|.|......        ||||:...:.:|  ||.    .||         |.|....
Human   260 PDCAPPAPGLPRGPCGP--------DCAPAAPSLPQDPCGPD----CAP---------PAPGLPP 303

  Fly   647 EFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQ 711
            :   |.|...  |..||  :.|..:|.|                     .....:::::::...:
Human   304 D---PCGSNC--APPDA--VRAAALPPQ---------------------TPPQTRRRRRAKITGR 340

  Fly   712 ESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC-IPTELWDFFYALCYINSTINPMCYALC 775
            |.||.:.|..::.:|::.|||:.::.:.:.|  |..| :|..|......|.|:||.:||:.|.:.
Human   341 ERKAMRVLPVVVGAFLLCWTPFFVVHITQAL--CPACSVPPRLVSAVTWLGYVNSALNPVIYTVF 403

  Fly   776 NATFRRTYVRIL 787
            ||.||..:.:.|
Human   404 NAEFRNVFRKAL 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	58/195 (30%)
		TM helix 1	106..132	CDD:320428	7/25 (28%)
		TM helix 2	139..165	CDD:320428	10/25 (40%)
		TM helix 3	177..207	CDD:320428	12/29 (41%)
		TM helix 4	219..242	CDD:320428	7/22 (32%)
		TM helix 5	265..294	CDD:320428	7/28 (25%)
		7tm_GPCRs	<707..783	CDD:475119	24/76 (32%)
		TM helix 6	716..738	CDD:410628	5/21 (24%)
		TM helix 7	751..776	CDD:410628	8/24 (33%)
DRD4	NP_000788.2	7tmA_D4_dopamine_R	38..411	CDD:320434	123/686 (18%)
		TM helix 1	38..62	CDD:320434	7/31 (23%)
		TM helix 2	69..95	CDD:320434	10/25 (40%)
		TM helix 3	108..138	CDD:320434	12/29 (41%)
		TM helix 4	150..173	CDD:320434	7/22 (32%)
		TM helix 5	189..218	CDD:320434	7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..264		17/216 (8%)
		4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P	249..312		22/182 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..336		3/39 (8%)
		TM helix 6	339..369	CDD:320434	8/29 (28%)
		TM helix 7	379..404	CDD:320434	8/24 (33%)