Protein Alignment mAChR-A and DRD3

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_000787.2
• Gene: DRD3 / 1814
• HGNCID: 3024
• Length: 400
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 122/717 - (17%)
• Similarity: 204/717 - (28%)
• Gaps: 332/717 - (46%)

  Fly    84 NQTNGTIGFETKGPRYSLASMV------VMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYF 142
            :|.:|.:.:.......:.||..      .:.:.|.||:  .|.||.:|.::...::.|||.:||.
Human     5 SQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILA--IVFGNGLVCMAVLKERALQTTTNYL 67

  Fly   143 LFSLAIADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSV 206
            :.|||:||..:..:.||......:. |.|....|.||.::.||.:...||:|||..||.|||.:|
Human    68 VVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAV 132

  Fly   207 TRPLTYR---AKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYI 268
            ..|:.|:   .:.:..|.|:||.|.|.::..:..|.::.: ...|..||    |.|    :|...
Human   133 VMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGF-NTTGDPTV----CSI----SNPDF 188

  Fly   269 TFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLL 333
            ...:::.:||.|..:...:|.||:...|:|:         :|....|.||.     .|....|.
Human   189 VIYSSVVSFYLPFGVTVLVYARIYVVLKQRR---------RKRILTRQNSQ-----CNSVRPGF- 238

  Fly   334 AFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIK 398
                           |:...|||
Human   239 ---------------PQQTLSPD------------------------------------------ 246

  Fly   399 EWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGV 463
                                           |..:|.....|:.:.|::
Human   247 -------------------------------PAHLELKRYYSICQDTAL---------------- 264

  Fly   464 RPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVN 528
                                                                             
Human   265 ----------------------------------------------------------------- 264

  Fly   529 GNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGG 593
                   .|.|....|....|:.:|.      ||.|.:.....::.:|..|:|..|.:...|
Human   265 -------GGPGFQERGGELKREEKTR------NSLSPTIAPKLSLEVRKLSNGRLSTSLKLG--- 313

  Fly   594 PGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSH 658
                                                          ||..|    .:||
Human   314 ----------------------------------------------PLQPR----GVPL------ 322

  Fly   659 AQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAIL 723
                                                                :|.||.:.::.:|
Human   323 ----------------------------------------------------REKKATQMVAIVL 335

  Fly   724 LSFIITWTPYNILVLIKPLTTCSDC-IPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
            .:||:.|.|:.:..::.  |.|..| :..||:.....|.|:||.:||:.|...|..||:.:::||
Human   336 GAFIVCWLPFFLTHVLN--THCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398

  Fly   788 TC 789
            :|
Human   399 SC 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	60/204 (29%)
		TM helix 1	106..132	CDD:320428	7/25 (28%)
		TM helix 2	139..165	CDD:320428	9/25 (36%)
		TM helix 3	177..207	CDD:320428	14/29 (48%)
		TM helix 4	219..242	CDD:320428	7/22 (32%)
		TM helix 5	265..294	CDD:320428	7/28 (25%)
		7tm_GPCRs	<707..783	CDD:475119	23/76 (30%)
		TM helix 6	716..738	CDD:410628	5/21 (24%)
		TM helix 7	751..776	CDD:410628	9/24 (38%)
DRD3	NP_000787.2	7tmA_D3_dopamine_R	30..394	CDD:320436	115/684 (17%)
		TM helix 1	31..57	CDD:320436	7/27 (26%)
		TM helix 2	64..87	CDD:320436	9/22 (41%)
		TM helix 3	103..133	CDD:320436	14/29 (48%)
		TM helix 4	150..168	CDD:320436	5/17 (29%)
		TM helix 5	185..210	CDD:320436	5/24 (21%)
		TM helix 6	322..352	CDD:320436	9/87 (10%)
		TM helix 7	362..387	CDD:320436	9/24 (38%)