Protein Alignment mAChR-A and gar-1

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001024402.1
• Gene: gar-1 / 180922
• WormBaseID: WBGene00001517
• Length: 713
• Species: Caenorhabditis elegans
• Alignment Length: 817
• Identity: 179/817 - (21%)
• Similarity: 313/817 - (38%)
• Gaps: 235/817 - (28%)

  Fly    99 YSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQL-QTISNYFLFSLAIADFAIGAISMPLFA 162
            ||:...:|:..:..:||..|:.||.||:::::|::.: :.:||.::.||||:|..||....|.|.
 Worm    19 YSIPVQIVVWIIIIVLSLETIIGNAMVVMAYRIERNISKQVSNRYIVSLAISDLIIGIEGFPFFT 83

  Fly   163 VTTILG-YWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIG 226
            |..:.| .||||.:.|.|||.|||.....|:|.:|:|:.|||.||.....|...::..:..::|.
 Worm    84 VYVLNGDRWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAKYLKWQSPTKTQLLIV 148

  Fly   227 AAWGISLLLWPPWIYSWPYIEGKRT-VPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWR 290
            .:|.:..:::...||.|..:.|:.| :...||...|: :|.|:..|..:|.::..:..|..||..
 Worm   149 MSWLLPAIIFGIMIYGWQAMTGQSTSMSGAECSAPFL-SNPYVNMGMYVAYYWTTLVAMLILYKG 212

  Fly   291 IWR-----ETKKRQKDLPNL----------QAG-------KKDSSKRSNSSDENTVVNHASGGLL 333
            |.:     |.|.:.|:..::          |.|       |.:..|...:..::...::.:|...
 Worm   213 IHQAAKNLEKKAKAKERRHIALILSQRLGTQVGVSLMLQSKAEKEKAEEAQKDSGYTSNQAGDAN 277

  Fly   334 AFAQVGGNDHDTWR---RPRSESSPDAESVYMT----NM-VIDSGYHGMHSRKSSIKSTNTIKKS 390
            ...:.|.::.:|.:   .|.|.::.:.|....|    |: ||:....|..||:.|       .:|
 Worm   278 NLRRFGFSEPETSQFRVDPNSNNNLNVEGSLNTENDQNLGVIEEERSGFLSRRES-------NES 335

  Fly   391 YTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYS 455
            |                                   |..|    .|..::..||:.|.
 Worm   336 Y-----------------------------------YPGP----HPTAANSRRCSEME------- 354

  Fly   456 MGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTAS---TTANVNT------------ 505
               .||       |||:....|..| |..|..:|...|..:||   ||.:.|.
 Worm   355 ---KVS-------LLSESDGVPSTR-PAKSYGRLSLRSRYSASESITTTHENDEKEVEKADSLQK 408

  Fly   506 --SGNGNGAINN------NNNASHNGNGAVN----------GNGAGNGSGIGLGTT--------- 543
              :.:..|::.|      .|..|:|.:...:          .|.....|.....:|
 Worm   409 LFADDELGSVLNFKEEKLKNTDSNNDSDTTSVILQRSRKYKKNKRPRSSRRSEHSTPRQIAKVKQ 473

  Fly   544 --GNATHRDSRTLPVINRINSRSVSQDSVYTI---------LIR-----LPSDGASSNAANGGGG 592
              |.|......::|..::..:..|.:...:.:         |||     .|..|:|||:.:
 Worm   474 AEGTAAQLIEESVPDDDQTETIEVKRTDRWVVSMKKRIARALIRRRSTTRPERGSSSNSDD---- 534

  Fly   593 GPGAGAAASASLSMQGDCAPSIK---------MIHEDGPTTTAAAAPLASAAATRRPLPSRDSEF 648
                     :|..::|:..|.::         .::.:....|::.             |.||
 Worm   535 ---------SSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQ-------------PGRD--- 574

  Fly   649 SLPLGRRMSHAQHDARLLNAKVIPKQLG---------KAGGGAAGGGVGGAHALMNARNAAKKKK 704
                  |::........|:|..:.:::.         |.        :....|.:...|..:|:.
 Worm   575 ------RLAPPNKTDTFLSASGVSRKISTISTVITREKV--------ISSIFAPIAVFNRGRKQT 625

  Fly   705 KSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTC-SDCIPTELWDFFYALCYINSTIN 768
            |: |||.. ||.:|::.|:..|.|.|:||.|:..:...  | .:|||:.|:...|.:||:||:.|
 Worm   626 KA-EKRAH-KAFRTITFIVGFFAILWSPYYIMATVYGF--CKGECIPSFLYTLSYYMCYLNSSGN 686

  Fly   769 PMCYALCNATFRRTYVRILTCKWHTRNREGMVRGVYN 805
            |..|||.|..||..::|             |.||.:|
 Worm   687 PFAYALANRQFRSAFMR-------------MFRGNFN 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	42/125 (34%)
		7tm_1	121..>314	CDD:278431	63/217 (29%)
gar-1	NP_001024402.1	7tm_4	39..>163	CDD:304433	41/123 (33%)
		7tm_1	41..>236	CDD:278431	60/195 (31%)
		7tm_4	<586..705	CDD:304433	39/143 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920