Protein Alignment mAChR-A and gar-3

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001024236.1
• Gene: gar-3 / 179962
• WormBaseID: WBGene00001519
• Length: 611
• Species: Caenorhabditis elegans
• Alignment Length: 821
• Identity: 277/821 - (33%)
• Similarity: 368/821 - (44%)
• Gaps: 266/821 - (32%)

  Fly    17 ILEPLFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGM 81
            :.:.|.|.:.||....|.|..:|                           :||:.....|.||
 Worm    19 LFQMLVKVINTSAENATKTAIAT---------------------------SSTSTPSFVDTYS-- 54

  Fly    82 YGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSL 146
                |:..:|.|.:        ||::..:.|:.:.||..||:|||:|||||||||||||||||||
 Worm    55 ----TSSLLGEEGR--------MVMIVVIGAMFALVTSLGNLMVMVSFKIDKQLQTISNYFLFSL 107

  Fly   147 AIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLT 211
            |:||.|||.||:|:|...|.:..|.||..:|..||.:|||.|||||||||:|||||||||||||:
 Worm   108 AVADIAIGVISIPMFTYYTAIQKWDLGYTMCQFWLCIDYLMSNASVLNLLLISFDRYFSVTRPLS 172

  Fly   212 YRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAA 276
            ||.:|||.:|..||...:.|||:||||||.||||||||.|.....|.:||::||.|:|.|||:||
 Worm   173 YRPRRTTKKALTMIACTYIISLILWPPWIISWPYIEGKFTAEPGTCVVQFLQTNPYVTVGTAVAA 237

  Fly   277 FYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSS----KRSNSSDENTVVNHASGGLLAFAQ 337
            ||.||||||.||.|::.||:||||:...|||.:..:|    :.|..|..|:.:
 Worm   238 FYLPVTIMCILYTRVYWETQKRQKEFGKLQATQTWASDVVDRPSTQSFRNSKM------------ 290

  Fly   338 VGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCI 402
                    |::.:..|                    ..|.|..:.||:.||.|    ||:::
 Worm   291 --------WKKVKKFS--------------------RRSMKRDVSSTSIIKSS----GSMRK--- 320

  Fly   403 AWWHSGREDSDDFAYEQEEPSDLGYATPVTI--ETPLQSSVSRCT--------------SMNVMR 451
                  :.:.|.:..:.        .||.|.  .:..:|.:..||              :||:
 Worm   321 ------KNNQDGYVEDS--------VTPCTSSRNSKRKSWLRNCTGKSNSSSEDSSEAVAMNL-- 369

  Fly   452 DNYSMGGS---VSGVRPPSILLSDVSP--TPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNG 511
            |:.|:..|   :||.|     ..::||  ||:|
 Worm   370 DDTSLSSSHFALSGSR-----RRNISPPCTPMP-------------------------------- 397

  Fly   512 AINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIR 576
              .|..:......||...||:..                .|:.|.....|:.|    ..||:||.
 Worm   398 --TNFEDEEQTDAGASMRNGSAR----------------FRSRPSDTGKNNNS----DTYTVLIE 440

  Fly   577 LPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPL 641
            |..:                |:..|..||   .|.|.:     |.|.:|           ..|..
 Worm   441 LNDE----------------GSRPSVRLS---SCEPYL-----DEPIST-----------RNRSK 470

  Fly   642 PSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKS 706
            ...:||..   .||.|       ||| |..|.:.|:              .|.|..:..:|.:|.
 Worm   471 SDCNSEID---ERRHS-------LLN-KQSPFKNGR--------------ILKNFSSQERKSEKE 510

  Fly   707 Q---EKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTC-----SDCIPTELWDFFYALCYI 763
            |   |::|||||||||||||.:||.||||||::|       |     .:.:|..||.|.|.||||
 Worm   511 QRKNERKQESKAAKTLSAILCAFIATWTPYNLIV-------CWEAFFPNTVPNVLWTFSYFLCYI 568

  Fly   764 NSTINPMCYALCNATFRRTYVRILTCKWHTRN---REGMVR 801
            ||||||:|||||||.||.||:|||.||:....   .:|.||
 Worm   569 NSTINPLCYALCNARFRHTYMRILRCKFKAERPTMNQGYVR 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	84/123 (68%)
		7tm_1	121..>314	CDD:278431	125/196 (64%)
gar-3	NP_001024236.1	7tm_4	77..>202	CDD:304433	84/124 (68%)
		7tm_1	82..>263	CDD:278431	121/180 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163725
Domainoid	1	1.000	352	1.000	Domainoid score	I526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20189
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1133
Isobase	1	0.950	-	0	Normalized mean entropy	S5092
OMA	1	1.010	-	-		QHG28765
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	1	1.000	-	-		FOG0001308
OrthoInspector	1	1.000	-	-		oto20311
orthoMCL	1	0.900	-	-		OOG6_108988
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2382
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890