DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-A and gar-2

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001368076.1	Gene:	gar-2 / 175893	WormBaseID:	WBGene00001518	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	765	Identity:	177/765 - (23%)
Similarity:	299/765 - (39%)	Gaps:	197/765 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTI-LG 168
            |::......||.|||.||:.|::|:.:||.::..:|||:|||||:|..||...:|::....: ..
Worm     6 VLLALFMLFLSIVTVIGNLAVLLSYYLDKNIRQPTNYFIFSLAISDLLIGLEGIPVYTAFYLNNN 70

  Fly   169 YWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISL 233
            .|..|.::||.||::||:...||:..:|.|:.|||:||.:|.|||..||..|..::|...|.:..
Worm    71 EWIWGDVLCDLWLSIDYIVCLASIYTVLGITVDRYYSVKKPATYRNWRTPGRVVLIIIFIWLVPS 135

  Fly   234 LLWPPWIYSWPYIEGK-RTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKK 297
            :|:...|:.:....|. |.:.:.|||:||: ||.|:..|..::.::..:.:|.:|||.|:|..||
Worm   136 ILFSVSIFGYGTFTGTGRILKETECYVQFM-TNPYLNMGMYISYYWTTLFVMLYLYWGIYRAAKK 199

  Fly   298 -------RQKDL--------PNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWR 347
                   :.|.|        |.:.....|:...|:.|..:|                .|....:|
Worm   200 LALKSDQKTKRLALLTEMRRPEVSVRTSDAGNSSSDSPNDT----------------SNSSKCFR 248

  Fly   348 RPRSESSPDAESVYMTNMVIDS------GYHGMHSRKSSIKSTNTIKK----------SYTCFGS 396
                 ::|...:|..|...:.:      .:..:|:........|.|.:          |...|..
Worm   249 -----TAPPTTTVQTTQTNVGTPPPVFRNHMTLHNNNMDFTKDNEIVRPPTPPDDNTYSNPNFSM 308

  Fly   397 IKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTS--------MNVMRDN 453
            |.|....            .:.::|||.:       ||   :.|.:.|.|        .|...:|
Worm   309 ISEQLTN------------GFSRQEPSSV-------IE---RESTAPCVSPEPSHASLENEFNEN 351

  Fly   454 Y-------------------SMGGSVSGVRPPSILLS---DVSPTPLPRPPLASISQLQEMSAVT 496
            :                   ||.|.....|..||.:|   .:..|....|.:..:..|:|...:
Worm   352 HHAHFKPELSLPFIDADSVSSMVGHDDLRRAMSIRISRSVSMQGTARATPVIEIVENLEEALKI- 415

  Fly   497 ASTTANVNTSGNGNGAINNNNNASHNG-NGAVNGNGAGNGSGIGLGTTGNATHRDSRT------- 553
            ......:....|.|......|...:.| |..:..|.....|     |:..:..::..|
Worm   416 CENLEELREDENKNEEEKQKNGLENGGMNHVIIANDEQQPS-----TSKESEQKEEMTPENHDPN 475

  Fly   554 -----LPVINRINS-RSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAP 612
                 |..::|:.| :|.:...|..::.::.|....|.              ..|:.:....|:|
Worm   476 EVKVPLIAVSRVESVKSTAGGKVRRLITQMRSHSIRSK--------------RKANKNKVSTCSP 526

  Fly   613 SIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGK 677
            .         :||:...|.::::.||.                        |..:...|..|.
Worm   527 K---------STTSLLLPPSTSSTTRE------------------------RTRHPVTITLQF-- 556

  Fly   678 AGGGAAGGGVGGAHALMNARNAAKKKK--KSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIK 740
                         .::::|.|..::||  ||:.:.:..||.:|::.||.||||.|||:.:|..|.
Worm   557 -------------QSVLSALNFFQRKKEYKSRSENRARKALRTITFILGSFIILWTPFYVLATIY 608

  Fly   741 PLTTCSDCIPT----ELWDFFYALCYINSTINPMCYALCNATFRRTYVRI 786
            ..  |..|..:    .|:...|.|||:||.:||.|||:.|..|::|..||
Worm   609 GF--CETCKASPSFNTLYTISYYLCYMNSPLNPFCYAMANQQFKKTLTRI 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	48/124 (39%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	69/209 (33%)
gar-2	NP_001368076.1	7tmA_mAChR_GAR-2-like	6..>199	CDD:320429	69/193 (36%)
		TM helix 1	8..32	CDD:320429	9/23 (39%)
		TM helix 2	41..63	CDD:320429	12/21 (57%)
		TM helix 3	80..102	CDD:320429	9/21 (43%)
		TM helix 4	125..141	CDD:320429	3/15 (20%)
		TM helix 5	168..191	CDD:320429	4/22 (18%)
		7tm_GPCRs	<575..653	CDD:421689	30/79 (38%)
		TM helix 6	578..608	CDD:410628	13/29 (45%)
		TM helix 7	621..646	CDD:410628	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920