DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and Hrh1

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_032311.2 Gene:Hrh1 / 15465 MGIID:107619 Length:488 Species:Mus musculus


Alignment Length:717 Identity:157/717 - (21%)
Similarity:247/717 - (34%) Gaps:260/717 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 KGPRYSLASMVVMGFVAAI--LSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAIS 157
            :|.|.::||..::..|..:  :|.|||..|::|:.:.:.:::|.|:.|.::.||::||..:||:.
Mouse    16 EGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVV 80

  Fly   158 MPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAA 222
            ||:..:..|:..|.||..:|..||::||:||.||:.::.|:..|||.||.:||.|...||..||:
Mouse    81 MPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRAS 145

  Fly   223 VMIGAAWGISLLLWPPWIYSWPYIEGKRTVP------KDECYIQFIETNQYITFGTALAAFYFPV 281
            ..|..||.:| .||...|..|.:.     .|      :|:|...|.... :....||:..||.|.
Mouse   146 ATILGAWFLS-FLWVIPILGWHHF-----TPLAPELREDKCETDFYNVT-WFKIMTAIINFYLPT 203

  Fly   282 TIMCFLYWRIWRETKK--RQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHD 344
            .:|.:.|.:|::..::  :.:.|.|                         |.|..|.::      
Mouse   204 LLMLWFYVKIYKAVRRHCQHRQLTN-------------------------GSLPTFLEI------ 237

  Fly   345 TWRRPRSESS------PDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIA 403
               :.|||.:      |..||.:           |:..|.|...:....:||             
Mouse   238 ---KLRSEDAKEGAKKPGKESPW-----------GVQKRPSRDPTGGLDQKS------------- 275

  Fly   404 WWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSI 468
                                        |.|.|      :.||..|    :|..|....|..|..
Mouse   276 ----------------------------TSEDP------KVTSPTV----FSQEGERETVTRPCF 302

  Fly   469 LLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAG 533
            .|..:...|:|                          .|:..|:..|:...|.            
Mouse   303 RLDVMQTQPVP--------------------------EGDARGSKANDQTLSQ------------ 329

  Fly   534 NGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGA 598
                         ...|.::|....||:..|..|..|........:|..:|..       ||.|.
Mouse   330 -------------PKMDEQSLSTCRRISETSEDQTLVDRQSFSRTTDSDTSIE-------PGLGK 374

  Fly   599 AASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDA 663
            ..:.|.|..|                      |.....|.:.|.|...::               
Mouse   375 VKARSRSNSG----------------------LDYIKVTWKRLRSHSRQY--------------- 402

  Fly   664 RLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFII 728
                                   |.|.|.                 .:|.||||.|..|:.:||:
Mouse   403 -----------------------VSGLHL-----------------NRERKAAKQLGCIMAAFIL 427

  Fly   729 TWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHT 793
            .|.||.|..::  :..|:.|....:..|...|.|||||:||:.|.|||..|::|:.:||    |.
Mouse   428 CWIPYFIFFMV--IAFCNSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKIL----HI 486

  Fly   794 RN 795
            |:
Mouse   487 RS 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 64/204 (31%)
TM helix 1 106..132 CDD:320428 7/27 (26%)
TM helix 2 139..165 CDD:320428 9/25 (36%)
TM helix 3 177..207 CDD:320428 14/29 (48%)
TM helix 4 219..242 CDD:320428 9/22 (41%)
TM helix 5 265..294 CDD:320428 8/28 (29%)
7tm_GPCRs <707..783 CDD:475119 29/75 (39%)
TM helix 6 716..738 CDD:410628 10/21 (48%)
TM helix 7 751..776 CDD:410628 11/24 (46%)
Hrh1NP_032311.2 7tmA_Histamine_H1R 29..480 CDD:320178 148/690 (21%)
TM helix 1 29..55 CDD:320178 7/25 (28%)
TM helix 2 62..88 CDD:320178 9/25 (36%)
TM helix 3 100..130 CDD:320178 14/29 (48%)
Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367 107..112 3/4 (75%)
TM helix 4 142..163 CDD:320178 8/21 (38%)
TM helix 5 187..216 CDD:320178 8/29 (28%)
TM helix 6 218..439 CDD:320178 68/453 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..337 26/204 (13%)
Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367 425..429 2/3 (67%)
TM helix 7 448..473 CDD:320178 11/24 (46%)

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