DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-A and Chrm4

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_006498717.1	Gene:	Chrm4 / 12672	MGIID:	88399	Length:	498	Species:	Mus musculus

Alignment Length:	757	Identity:	234/757 - (30%)
Similarity:	313/757 - (41%)	Gaps:	275/757 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TTTASPAGYSPGYPGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMV 105
            |...||.|:|            ..|.|         |.:|...||:...:  .|.........||
Mouse    10 TAHLSPVGFS------------MANFT---------PVNGSSANQSVRLV--TTAHNHLETVEMV 51

  Fly   106 VMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYW 170
            .:..|...||.|||.||::||:|.|:::||||::||||||||.||..|||.||.|:.:..|.|||
Mouse    52 FIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTLYIIKGYW 116

  Fly   171 PLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLL 235
            |||.:|||.||||||:.|||||:|||||||||||.||:||||.|:|||..|.:||.|||.:|.:|
Mouse   117 PLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVL 181

  Fly   236 WPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKR-Q 299
            |.|.|..|.::.||||||.::|:|||: :|..:|||||:||||.||.||..||..|...::.| .
Mouse   182 WAPAILFWQFVVGKRTVPDNQCFIQFL-SNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVH 245

  Fly   300 KDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTN 364
            |..|.   |.|:...::                |||.:                ||
Mouse   246 KHRPE---GPKEKKAKT----------------LAFLK----------------SP--------- 266

  Fly   365 MVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYAT 429
                       ..|.|||.
Mouse   267 -----------LMKPSIKK---------------------------------------------- 274

  Fly   430 PVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSA 494
                  |.....||....|         |.:....||::      |.| |||
Mouse   275 ------PPPGGASREELRN---------GKLEEAPPPAL------PPP-PRP------------- 304

  Fly   495 VTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINR 559
            |....|:|.::||:   |..|.......                .|.||..||   :..||. ..
Mouse   305 VADKDTSNESSSGS---ATQNTKERPPT----------------ELSTTEAAT---TPALPA-PT 346

  Fly   560 INSRSVSQDSVYT-ILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPT 623
            :..|:::..|.:: |.|.....|:                          :|..:|:::    |.
Mouse   347 LQPRTLNPASKWSKIQIVTKQTGS--------------------------ECVTAIEIV----PA 381

  Fly   624 TTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVG 688
            |.|...|.|:.|                  |:.:..
Mouse   382 TPAGMRPAANVA------------------RKFASI----------------------------- 399

  Fly   689 GAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTEL 753
                   |||..:||:  |...:|.|..:|:.||||:||:||||||::||:.  |.|..|||..:
Mouse   400 -------ARNQVRKKR--QMAARERKVTRTIFAILLAFILTWTPYNVMVLVN--TFCQSCIPERV 453

  Fly   754 WDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHTRN 795
            |...|.|||:||||||.|||||||||::|:..:|.|::  ||
Mouse   454 WSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQY--RN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	81/123 (66%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	112/193 (58%)
Chrm4	XP_006498717.1	7tmA_mAChR_M4	51..483	CDD:341344	216/679 (32%)
		TM helix 1	53..77	CDD:341344	11/23 (48%)
		TM helix 2	86..108	CDD:341344	16/21 (76%)
		TM helix 3	124..146	CDD:341344	17/21 (81%)
		TM helix 4	169..185	CDD:341344	8/15 (53%)
		TM helix 5	211..234	CDD:341344	14/22 (64%)
		TM helix 6	415..440	CDD:341344	14/24 (58%)
		TM helix 7	451..476	CDD:341344	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43823
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920