Protein Alignment mAChR-A and LOC116411706

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_031760361.1
• Gene: LOC116411706 / 116411706
• XenbaseID: XB-GENE-29097575
• Length: 402
• Species: Xenopus tropicalis
• Alignment Length: 714
• Identity: 130/714 - (18%)
• Similarity: 213/714 - (29%)
• Gaps: 358/714 - (50%)

  Fly    84 NQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAI 148
            ||||.:: .:..|.:....:|:::..|.:.|..|||.||.:|:::|..|::|:..||:||.:|||
 Frog    24 NQTNTSL-VDVMGTQSPQITMIILVTVISCLILVTVLGNTLVILAFIEDRRLRNRSNFFLLNLAI 87

  Fly   149 ADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYR 213
            .||.|||..:|.:......|.|.||..:|..||.:|.|...||..|:::||:||:.|||..:.:|
 Frog    88 CDFFIGAFCIPFYVPYVFTGKWLLGKFLCKLWLIVDNLMCTASAFNVVLISYDRFLSVTMAVLHR 152

  Fly   214 A-KRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAF 277
            : ::...|..:.:...|.::.||:.|.|..|.|::|.:::|.|.|...:... .|...|.:...|
 Frog   153 SIEKEHGRTVLNMALVWILASLLYSPAIIFWEYVDGDKSIPTDLCLPGYFYA-WYFLLGASTFDF 216

  Fly   278 YFPVTIMCF----LYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQV 338
            ..|:..:.|    ||..|...::|:|..:             ::..|.|...|.|...:     :
 Frog   217 LLPLLSISFFNLSLYCNIRSRSRKKQHIV-------------TSPIDSNLDGNPARPYI-----I 263

  Fly   339 GGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTI-----KKSYTCFGSIK 398
            .|||                            :|     ..::|..||.     |:|..||.|
 Frog   264 SGND----------------------------FH-----NGAVKDLNTPQYKKGKRSLCCFFS-- 293

  Fly   399 EWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGV 463
                                                             ||:
 Frog   294 -------------------------------------------------NVL------------- 296

  Fly   464 RPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVN 528
                              ||
 Frog   297 ------------------PL--------------------------------------------- 298

  Fly   529 GNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGG 593
                               |||.:|:    |.|        |:.|.:
 Frog   299 -------------------HRDQQTV----RYN--------VHVIKL------------------ 314

  Fly   594 PGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSH 658
                                                             |||
 Frog   315 -------------------------------------------------SRD------------- 317

  Fly   659 AQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAIL 723
                                                                  .|.||:||.::
 Frog   318 ------------------------------------------------------KKIAKSLSVLV 328

  Fly   724 LSFIITWTPYNILVLIKPLTTCSD-CIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRI 786
            ..|.:.|.||::|:.|:  ..|.| ||.:..:|..:.|.:|||::||..|.||:.:||:.:.::
 Frog   329 CVFGMCWAPYSLLMTIR--AACHDNCIDSYWYDITFWLLWINSSVNPFLYPLCHESFRKAFAKV 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	65/199 (33%)
		TM helix 1	106..132	CDD:320428	9/25 (36%)
		TM helix 2	139..165	CDD:320428	13/25 (52%)
		TM helix 3	177..207	CDD:320428	13/29 (45%)
		TM helix 4	219..242	CDD:320428	6/22 (27%)
		TM helix 5	265..294	CDD:320428	8/32 (25%)
		7tm_GPCRs	<707..783	CDD:475119	27/76 (36%)
		TM helix 6	716..738	CDD:410628	9/21 (43%)
		TM helix 7	751..776	CDD:410628	9/24 (38%)
LOC116411706	XP_031760361.1	7tmA_Histamine_H3R_H4R	44..387	CDD:320176	124/688 (18%)
		TM helix 1	45..71	CDD:320176	9/25 (36%)
		TM helix 2	78..105	CDD:320176	13/26 (50%)
		TM helix 3	116..146	CDD:320176	13/29 (45%)
		TM helix 4	161..179	CDD:320176	3/17 (18%)
		TM helix 5	204..234	CDD:320176	7/30 (23%)
		TM helix 6	315..345	CDD:320176	13/96 (14%)
		TM helix 7	355..380	CDD:320176	9/24 (38%)