DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and CHRM5

DIOPT Version :9

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_001307846.1 Gene:CHRM5 / 1133 HGNCID:1954 Length:532 Species:Homo sapiens


Alignment Length:738 Identity:233/738 - (31%)
Similarity:312/738 - (42%) Gaps:245/738 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 YGNQT--NGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLF 144
            |.|.|  |||........|:.|..::.:..|.|::|.:|:.|||:||||||::.||:|::||:|.
Human     6 YHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLL 70

  Fly   145 SLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRP 209
            |||.||..||..||.|:....::|.|.||.:.||.||||||:||||||:|||:||||||||:|||
Human    71 SLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRP 135

  Fly   210 LTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTAL 274
            ||||||||..||.:|||.||.||.:||.|.|..|.|:.||||||.|||.|||: :...||||||:
Human   136 LTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFL-SEPTITFGTAI 199

  Fly   275 AAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVG 339
            ||||.||::|..||.||:|||:||.|||.:||                                 
Human   200 AAFYIPVSVMTILYCRIYRETEKRTKDLADLQ--------------------------------- 231

  Fly   340 GNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAW 404
            |:|                                           ::.|:              
Human   232 GSD-------------------------------------------SVTKA-------------- 239

  Fly   405 WHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSIL 469
                         |:.:|:          ...|..|..||                         
Human   240 -------------EKRKPA----------HRALFRSCLRC------------------------- 256

  Fly   470 LSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGN 534
                     |||.||   |.:...|..:|:..:.:|:|..:.|                      
Human   257 ---------PRPTLA---QRERNQASWSSSRRSTSTTGKPSQA---------------------- 287

  Fly   535 GSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAA 599
                    ||          |..|...:..::..|.|      ||......        |.....
Human   288 --------TG----------PSANWAKAEQLTTCSSY------PSSEDEDK--------PATDPV 320

  Fly   600 ASASLSMQGDCAPSIKMIHEDGPTTTAAAAP----------LASAAATRRPLPSRDSEFSLPL-- 652
            .......||..:|..:...|:...|...|..          |.|.||..||...:...:...|  
Human   321 LQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVV 385

  Fly   653 ----GRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKR--- 710
                .:..::..|     ..|::|.....|...:..|           .|.....:.::.||   
Human   386 KADGNQETNNGCH-----KVKIMPCPFPVAKEPSTKG-----------LNPNPSHQMTKRKRVVL 434

  Fly   711 -QESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYAL 774
             :|.|||:|||||||:||||||||||:||:.  |.|..|:|..||...|.|||:|||:||:||||
Human   435 VKERKAAQTLSAILLAFIITWTPYNIMVLVS--TFCDKCVPVTLWHLGYWLCYVNSTVNPICYAL 497

  Fly   775 CNATFRRTYVRILTCKWHTRNRE 797
            ||.|||:|:..:|.|:|..:..|
Human   498 CNRTFRKTFKMLLLCRWKKKKVE 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tm_4 117..>241 CDD:304433 78/123 (63%)
7tm_1 121..>314 CDD:278431 119/192 (62%)
CHRM5NP_001307846.1 7tm_4 40..>167 CDD:304433 79/126 (63%)
7tm_1 47..>225 CDD:278431 114/178 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..294 10/74 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 349 1.000 Domainoid score I1027
eggNOG 1 0.900 - - E1_KOG4220
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 385 1.000 Inparanoid score I2042
Isobase 1 0.950 - 0 Normalized mean entropy S5092
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1245472at2759
OrthoFinder 1 1.000 - - FOG0001308
OrthoInspector 1 1.000 - - otm41771
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2382
SonicParanoid 1 1.000 - - X324
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.910

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