| Sequence 1: | NP_523844.2 | Gene: | mAChR-A / 37892 | FlyBaseID: | FBgn0000037 | Length: | 805 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000729.2 | Gene: | CHRM1 / 1128 | HGNCID: | 1950 | Length: | 460 | Species: | Homo sapiens |
| Alignment Length: | 728 | Identity: | 222/728 - (30%) |
|---|---|---|---|
| Similarity: | 291/728 - (39%) | Gaps: | 301/728 - (41%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 87 NGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADF 151
Fly 152 AIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKR 216
Fly 217 TTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPV 281
Fly 282 TIMCFLYWRIWRETKKRQKDLPNLQ--------AGKKDSSKRSNSSDENTVVNHASGGLLAFAQV 338
Fly 339 GGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIA 403
Fly 404 WWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSI 468
Fly 469 LLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAG 533
Fly 534 NGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGA 598
Fly 599 AASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDA 663
Fly 664 RLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFII 728
Fly 729 TWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCKWHT 793
Fly 794 R------NREGMV 800 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| mAChR-A | NP_523844.2 | 7tm_4 | 117..>241 | CDD:304433 | 77/123 (63%) |
| 7tm_1 | 121..>314 | CDD:278431 | 116/200 (58%) | ||
| CHRM1 | NP_000729.2 | TM helix 1 | 28..52 | CDD:341356 | 11/23 (48%) |
| TM helix 2 | 61..83 | CDD:341356 | 14/21 (67%) | ||
| TM helix 3 | 99..121 | CDD:341356 | 17/21 (81%) | ||
| TM helix 4 | 144..160 | CDD:341356 | 8/15 (53%) | ||
| TM helix 5 | 186..209 | CDD:341356 | 16/22 (73%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 225..256 | 12/96 (13%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 274..297 | 8/117 (7%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 310..351 | 11/80 (14%) | |||
| TM helix 6 | 364..386 | CDD:341356 | 17/21 (81%) | ||
| TM helix 7 | 397..422 | CDD:341356 | 17/24 (71%) | ||
| 7tmA_mAChR_M1 | 26..429 | CDD:341356 | 209/685 (31%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 349 | 1.000 | Domainoid score | I1027 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG4220 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H20189 | |
| Inparanoid | 1 | 1.050 | 385 | 1.000 | Inparanoid score | I2042 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S5092 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1245472at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001308 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41771 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24247 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2382 |
| SonicParanoid | 1 | 1.000 | - | - | X324 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 14 | 13.910 | |||||