Protein Alignment mAChR-A and HRH3

DIOPT Version :9

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_005260323.1
• Gene: HRH3 / 11255
• HGNCID: 5184
• Length: 453
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 144/699 - (20%)
• Similarity: 232/699 - (33%)
• Gaps: 310/699 - (44%)

  Fly    99 YSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAV 163
            :|.|...|:..:.|:|...||.||.:||::|..|..|:|.:|:||.:|||:||.:||..:||:..
Human    29 FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVP 93

  Fly   164 TTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKR-TTNRAAVMIGA 227
            ..:.|.|..|..:|..||.:|||...:|..|:::||:||:.||||.::|||:: .|.||...:..
Human    94 YVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLL 158

  Fly   228 AWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCF----LY 288
            .|.::.||:.|.|.||.|:.|..::|:..||.:|. .|.|.....:...|:.|...:.|    :|
Human   159 VWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFF-YNWYFLITASTLEFFTPFLSVTFFNLSIY 222

  Fly   289 WRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSES 353
            ..|.|.|:.|
Human   223 LNIQRRTRLR------------------------------------------------------- 232

  Fly   354 SPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYE 418
                         :|                                      ..||
Human   233 -------------LD--------------------------------------GARE-------- 238

  Fly   419 QEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPL 483
                                                     .:|..||    .:..|:|.|.|..
Human   239 -----------------------------------------AAGPEPP----PEAQPSPPPPPGC 258

  Fly   484 ASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATH 548
            ....|                                           .|:|..:.|       |
Human   259 WGCWQ-------------------------------------------KGHGEAMPL-------H 273

  Fly   549 RDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPS 613
            |             ..|.:.:|          ||.:..|..|||| |.|:.||
Human   274 R-------------YGVGEAAV----------GAEAGEATLGGGG-GGGSVAS------------ 302

  Fly   614 IKMIHEDGPTTTAAAAPLASAAATRRPLP----SRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQ 674
                    ||:::.    :|:..|.||..    |:.|..|..|.:||.
Human   303 --------PTSSSG----SSSRGTERPRSLKRGSKPSASSASLEKRMK----------------- 338

  Fly   675 LGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLI 739
                               |.:::..::.:.|:::    |.||:|:.|:..|.:.|.||.:|::|
Human   339 -------------------MVSQSFTQRFRLSRDR----KVAKSLAVIVSIFGLCWAPYTLLMII 380

  Fly   740 KPLTTC-SDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
            :  ..| ..|:|...::..:.|.:.||.:||:.|.||:.:|||.:.::|
Human   381 R--AACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	51/124 (41%)
		7tm_1	121..>314	CDD:278431	68/197 (35%)
HRH3	XP_005260323.1	7tm_1	51..412	CDD:278431	130/660 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010