Protein Alignment mAChR-A and LOC100498398

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_002931741.2
• Gene: LOC100498398 / 100498398
• XenbaseID: XB-GENE-29084187
• Length: 456
• Species: Xenopus tropicalis
• Alignment Length: 758
• Identity: 147/758 - (19%)
• Similarity: 246/758 - (32%)
• Gaps: 340/758 - (44%)

  Fly    46 PAGYSPGY-PGTTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGF 109
            |||..|.: .|..........|.:..|:||.:.....||              ::|.:..:::..
 Frog    10 PAGDMPAHLAGFNRSAGEVVQLGNACAAGLAEEQLQHYG--------------QFSSSVSIILAV 60

  Fly   110 VAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGP 174
            :.|::...||.||.:|:::|.::|.|:|..|:|..:||||||.:|...:||:....:.|.|..|.
 Frog    61 LMALMVLATVLGNALVILAFVVEKGLRTQGNFFFLNLAIADFLVGGFCIPLYIPYVLTGQWKFGK 125

  Fly   175 IVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVM-IGAAWGISLLLWPP 238
            .:|..||.:|||...|||.|:::||:||:.|||:.::|||::...|.||: :...|..:.||:.|
 Frog   126 GLCKLWLVMDYLLCTASVFNIVLISYDRFISVTKAVSYRAQKGMTRNAVLKMLIVWVAAFLLYGP 190

  Fly   239 WIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFP-VTIMCF---LYWRIWRETKKRQ 299
            .|.:|.||.....:|:.|||::|. .|.|.....:...|:.| :::..|   :|..|.|.|..|.
 Frog   191 AIITWEYIARTTILPEGECYVEFY-YNWYFLMIASTIEFFTPFISVTYFNLSIYINIKRRTMMRN 254

  Fly   300 KDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTN 364
            :::                                 ||  |.:|             .|..:.
 Frog   255 EEM---------------------------------AQ--GQEH-------------CELTFQ-- 269

  Fly   365 MVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYAT 429
                                          |..||..|.:               .:|:|..|.
 Frog   270 ------------------------------GKRKEHLIFF---------------VKPADRPYG- 288

  Fly   430 PVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSA 494
                                  :....||::|...|.::
 Frog   289 ----------------------EAKKQGGTLSPAMPSAV-------------------------- 305

  Fly   495 VTASTTANVNTSGNGNGA---------INNNNNASHNGNGAVNGNGAGNGSGIGLGTTGNATHRD 550
                          ||||         :|.|.:
 Frog   306 --------------GNGAQELESPMLDLNINQD-------------------------------- 324

  Fly   551 SRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIK 615
               ||.:....|...|||..|.                         :|.:|..:|:.|.|.||
 Frog   325 ---LPPLQVEVSAKKSQDCFYK-------------------------SAENACSNMRPDMASSI- 360

  Fly   616 MIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGG 680
                                                                             
 Frog   361 ----------------------------------------------------------------- 360

  Fly   681 GAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTC 745
                               |.:.:.|::||    .||:|:.|:..|.:.|.||.:|::|:  ..|
 Frog   361 -------------------ANRFRLSRDKR----VAKSLAIIVCVFGLCWAPYTLLMIIR--AAC 400

  Fly   746 -SDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
             ..|:...|::..:.|.::||.|||:.|.||:.:||:.::::|
 Frog   401 HGRCVQDYLYEISFWLLWLNSAINPVLYPLCHMSFRKAFMKLL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	70/199 (35%)
		TM helix 1	106..132	CDD:320428	7/25 (28%)
		TM helix 2	139..165	CDD:320428	11/25 (44%)
		TM helix 3	177..207	CDD:320428	15/29 (52%)
		TM helix 4	219..242	CDD:320428	8/23 (35%)
		TM helix 5	265..294	CDD:320428	7/32 (22%)
		7tm_GPCRs	<707..783	CDD:475119	26/76 (34%)
		TM helix 6	716..738	CDD:410628	9/21 (43%)
		TM helix 7	751..776	CDD:410628	9/24 (38%)
LOC100498398	XP_002931741.2	7tmA_Histamine_H3R	56..439	CDD:320423	134/692 (19%)
		TM helix 1	57..83	CDD:320423	7/25 (28%)
		TM helix 2	90..117	CDD:320423	11/26 (42%)
		TM helix 3	128..158	CDD:320423	15/29 (52%)
		TM helix 4	173..191	CDD:320423	5/17 (29%)
		TM helix 5	216..246	CDD:320423	6/29 (21%)
		TM helix 6	367..397	CDD:320423	12/33 (36%)
		TM helix 7	407..432	CDD:320423	9/24 (38%)