DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-A and hrh1

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_031757131.1	Gene:	hrh1 / 100495566	XenbaseID:	XB-GENE-6031155	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	721	Identity:	153/721 - (21%)
Similarity:	242/721 - (33%)	Gaps:	241/721 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 QTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIA 149
            |||.:|  ...|.....||   :|.....:|.:||..|::|:.:.:.:::|.|:.|.::.||:||
Frog     3 QTNQSI--VQNGTEIHSAS---LGLALGTISALTVVLNILVLYAVRTERKLHTVGNLYIVSLSIA 62

  Fly   150 DFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRA 214
            |..:||..|||..|..:...|.||...|..||::||:||.||:.:|.|:..|||.|:.:||.|..
Frog    63 DLIVGAAVMPLNIVYLLNREWILGRPACLFWLSMDYVASTASIFSLFILCIDRYRSIQQPLRYLK 127

  Fly   215 KRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIE--GKRTVPKDECYIQFIETNQYITFGTALAAF 277
            .||..||::||..||.:| ..|...|..|....  |.|:||:..|..:|.:...:... ||...|
Frog   128 YRTKTRASLMISGAWLLS-FTWVVPILGWHVFANGGIRSVPESTCETEFHKVTWFKVL-TATLNF 190

  Fly   278 YFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGND 342
            |.|..:|.:.|.:|::..::.
Frog   191 YIPSLLMLWFYAKIYKAVREH-------------------------------------------- 211

  Fly   343 HDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHS 407
                              |....|::..:...:..| .::|...:|...:|   .|..|
Frog   212 ------------------YQHREVVNGSFQLFYDSK-LVQSVRVLKGQQSC---TKTQC------ 248

  Fly   408 GREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSD 472
              :|.:....|...|:..   ||::.|    ...||.|......::|   |...|...     .|
Frog   249 --KDGNLTVPEMNFPAQY---TPISKE----FRQSRSTQEKDPVEDY---GKQKGFSH-----CD 296

  Fly   473 VSPTPLPRPPLASI--SQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNG 535
            .:...|...|||.|  |..:..:.||.:           .||:..:|
Frog   297 NNVFKLHCFPLAIIQGSPQECRNYVTVT-----------RGALEEHN------------------ 332

  Fly   536 SGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAA 600
                                .:.......:|::..:                       ...|:.
Frog   333 --------------------CLRPRQREEISEEHTF-----------------------AEAASC 354

  Fly   601 SASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARL 665
            ...||..|                                    .|....| ||..:....:.|.
Frog   355 MVDLSQVG------------------------------------KSNMEAP-GRTEARLSGNFRY 382

  Fly   666 LNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITW 730
            |.                       |.....|..:|:..:.....:|.||||.|..|:.:|::.|
Frog   383 LK-----------------------HTWERFRTHSKQHIQGLHMNRERKAAKQLGFIMAAFMLCW 424

  Fly   731 TPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL-------T 788
            .||.:|.::  :..|.:|.......|...|.|||||:||:.|.|||..|::|:.:|.       .
Frog   425 IPYFVLFMV--IAFCHNCCNHNFHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKIFHVELNCGE 487

  Fly   789 CKWHTR 794
            ||...|
Frog   488 CKKENR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	49/123 (40%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	63/194 (32%)
hrh1	XP_031757131.1	7tmA_Histamine_H1R	18..475	CDD:320178	143/684 (21%)
		TM helix 1	20..44	CDD:320178	6/23 (26%)
		TM helix 2	53..75	CDD:320178	11/21 (52%)
		TM helix 3	91..113	CDD:320178	10/21 (48%)
		TM helix 4	136..152	CDD:320178	6/16 (38%)
		TM helix 5	179..317	CDD:320178	35/227 (15%)
		TM helix 6	410..432	CDD:320178	9/21 (43%)
		TM helix 7	443..468	CDD:320178	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010