DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-A and chrm3

DIOPT Version :10

Sequence 1:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster
Sequence 2:XP_002935876.2 Gene:chrm3 / 100493547 XenbaseID:XB-GENE-940647 Length:588 Species:Xenopus tropicalis


Alignment Length:771 Identity:252/771 - (32%)
Similarity:336/771 - (43%) Gaps:253/771 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 TLLTALFENLTSTAASGLYDPYSGMYGNQT---------------------------NGT----- 89
            ||||.| .|::|||.:.|   .||...|.|                           ||.     
 Frog     7 TLLTIL-ANISSTAKTLL---QSGDLYNATEITFWSNDITKFFYNTSDIKDEVNISDNGNYTERD 67

  Fly    90 -IGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAI 153
             :|..|....:.:||.      :.|::.|||.||::|:::||::|||:|::||||.|||.||..|
 Frog    68 YLGGHTVWQVFLIASF------SGIIALVTVIGNILVILAFKVNKQLKTVNNYFLLSLACADLII 126

  Fly   154 GAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTT 218
            |.|||.||....|:.:|.:|.:.||.||.:||:||||||:|||:||||||||:|||||||.||||
 Frog   127 GVISMNLFTTYIIMDHWIMGSLACDLWLMIDYVASNASVMNLLVISFDRYFSITRPLTYRTKRTT 191

  Fly   219 NRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTI 283
            .||.:|||.||.||.:||.|.|..|.|..||||||.|||:|||. |...||||||:||||.||:|
 Frog   192 KRAGIMIGLAWIISFILWAPAILFWQYFVGKRTVPSDECFIQFF-TEPIITFGTAIAAFYLPVSI 255

  Fly   284 MCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRR 348
            |..|||||::||:||.|:|..||                     ||||.|   :|.|..|.|   
 Frog   256 MTILYWRIYKETEKRTKELAGLQ---------------------ASGGKL---EVPGLSHRT--- 293

  Fly   349 PRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIK-KSYTCFGSIKEWCIAWWHSGREDS 412
                                    |.....|:.|....|| .|.|.:    .||...:......|
 Frog   294 ------------------------GNAKGNSNYKIQRNIKFSSRTRY----SWCTFRFKPKMCKS 330

  Fly   413 DDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTP 477
            |....||::.|                                                      
 Frog   331 DKKQIEQDQSS------------------------------------------------------ 341

  Fly   478 LPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGT 542
                                      :.|.|.|.|     |||                   |..
 Frog   342 --------------------------SESWNHNDA-----NAS-------------------LDN 356

  Fly   543 TGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQ 607
            :|.:...|:...|            .::|:|:::|                ||..:..|.:.|..
 Frog   357 SGTSDEEDAPENP------------RAIYSIVLKL----------------PGHNSVLSKTKSQS 393

  Fly   608 GDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIP 672
            .:...:.|.:.:.||..........:   ::|.|.::|...|:.|..:..|:.:.:....|. :|
 Frog   394 SNQGNTSKGMQKSGPQPKELRFKNLN---SQRNLQNKDESISVSLSPQTDHSMNTSSKTTAP-LP 454

  Fly   673 ---KQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYN 734
               |::..|...||           ..||...|:|: ....:|.|||:|||||||:|||||.|||
 Frog   455 ISFKEIALAKRFAA-----------KTRNQITKRKR-MSLIKEKKAAQTLSAILLAFIITWAPYN 507

  Fly   735 ILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRILTCK 790
            |:||:.  |.|..|||...|:..|.||||||||||:||||||.|||.|:..:|.|:
 Frog   508 IMVLVN--TFCESCIPRIYWNLGYWLCYINSTINPICYALCNKTFRTTFKILLLCQ 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 117/194 (60%)
TM helix 1 106..132 CDD:320428 9/25 (36%)
TM helix 2 139..165 CDD:320428 16/25 (64%)
TM helix 3 177..207 CDD:320428 23/29 (79%)
TM helix 4 219..242 CDD:320428 13/22 (59%)
TM helix 5 265..294 CDD:320428 19/28 (68%)
7tm_GPCRs <707..783 CDD:475119 48/75 (64%)
TM helix 6 716..738 CDD:410628 17/21 (81%)
TM helix 7 751..776 CDD:410628 16/24 (67%)
chrm3XP_002935876.2 7tmA_mAChR_M3 75..>279 CDD:320426 123/231 (53%)
TM helix 1 79..105 CDD:320426 11/31 (35%)
TM helix 2 112..139 CDD:320426 16/26 (62%)
TM helix 3 150..180 CDD:320426 23/29 (79%)
TM helix 4 192..215 CDD:320426 13/22 (59%)
TM helix 5 237..266 CDD:320426 19/28 (68%)
7tm_GPCRs <483..563 CDD:475119 51/81 (63%)
TM helix 6 489..511 CDD:320426 17/21 (81%)
TM helix 7 522..547 CDD:320426 16/24 (67%)

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