Protein Alignment mAChR-A and drd4

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_002937535.2
• Gene: drd4 / 100486482
• XenbaseID: XB-GENE-990215
• Length: 414
• Species: Xenopus tropicalis
• Alignment Length: 711
• Identity: 126/711 - (17%)
• Similarity: 209/711 - (29%)
• Gaps: 348/711 - (48%)

  Fly    81 MYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFS 145
            |..|.:|.| ......|.|:..:: |.||   ||....:.|||:|.:|...:|.|:|.:|||:.|
 Frog    44 MVHNISNHT-SHSAVDPHYNFLAL-VFGF---ILIVCIICGNVLVCLSVCTEKALKTTTNYFIVS 103

  Fly   146 LAIADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRP 209
            ||:||..:..:.:||:..|..: |.|.|..::||..:.:|.:...||:.||..||.||:.:|:.|
 Frog   104 LAVADLLLAVLVLPLYVYTEFVGGVWTLSLVLCDVLMTMDVMLCTASIFNLCAISVDRFIAVSIP 168

  Fly   210 LTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTAL 274
            |.|..::..||...:|...|..:..:..|.|:      |...|...:..:..:|.|.||.: :::
 Frog   169 LNYNRRQVDNRQLFLISTTWIFAFAVASPVIF------GLNNVADRDPTMCKLEDNNYIVY-SSV 226

  Fly   275 AAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVG 339
            .:|:.|..||..||..:
 Frog   227 CSFFIPCPIMLVLYCAM------------------------------------------------ 243

  Fly   340 GNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAW 404
                                           :||                       :::|
 Frog   244 -------------------------------FHG-----------------------LRKW---- 250

  Fly   405 WHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPS-- 467
                           ||          |.:|.|:|.:|                  .|::||.
 Frog   251 ---------------EE----------TRKTKLRSHMS------------------PGLKPPQCP 272

  Fly   468 ILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNGNGA 532
            .||.|.|||.         |:|.|:
 Frog   273 ALLLDRSPTD---------SKLDEL---------------------------------------- 288

  Fly   533 GNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNAANGGGGGPGAG 597
                                                                             
 Frog   289 ----------------------------------------------------------------- 288

  Fly   598 AAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMSHAQHD 662
                 :|..|||| |..|...::|......|.|                           |.::
 Frog   289 -----NLYDQGDC-PFPKSYVDNGHGIQTVAYP---------------------------HLKY- 319

  Fly   663 ARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAILLSFI 727
                                             :.|...::|:::...:|.||.:.|..::.:|:
 Frog   320 ---------------------------------STNMEPERKQAKINGRERKAMRVLPVVVGAFL 351

  Fly   728 ITWTPYNILVLIKPLTTCSDC-IPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
            ..|||:.::.:.:.|  |..| ||.:|......|.|:||.:||:.|.:.|..||..:.::|
 Frog   352 FCWTPFFVVHITRAL--CESCYIPEQLISIVTWLGYVNSALNPVIYTIFNTEFRNYFRKVL 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	60/195 (31%)
		TM helix 1	106..132	CDD:320428	10/25 (40%)
		TM helix 2	139..165	CDD:320428	10/25 (40%)
		TM helix 3	177..207	CDD:320428	11/29 (38%)
		TM helix 4	219..242	CDD:320428	6/22 (27%)
		TM helix 5	265..294	CDD:320428	9/28 (32%)
		7tm_GPCRs	<707..783	CDD:475119	24/76 (32%)
		TM helix 6	716..738	CDD:410628	5/21 (24%)
		TM helix 7	751..776	CDD:410628	8/24 (33%)
drd4	XP_002937535.2	7tmA_D4_dopamine_R	63..406	CDD:320434	119/685 (17%)
		TM helix 1	64..90	CDD:320434	10/29 (34%)
		TM helix 2	97..123	CDD:320434	10/25 (40%)
		TM helix 3	136..166	CDD:320434	11/29 (38%)
		TM helix 4	178..201	CDD:320434	6/28 (21%)
		TM helix 5	217..246	CDD:320434	9/108 (8%)
		TM helix 6	334..364	CDD:320434	8/29 (28%)
		TM helix 7	374..399	CDD:320434	8/24 (33%)