Protein Alignment mAChR-A and chrm2

DIOPT Version :10

• Sequence 1: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_002942846.2
• Gene: chrm2 / 100485603
• XenbaseID: XB-GENE-6034896
• Length: 470
• Species: Xenopus tropicalis
• Alignment Length: 719
• Identity: 215/719 - (29%)
• Similarity: 300/719 - (41%)
• Gaps: 276/719 - (38%)

  Fly    84 NQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSLAI 148
            :.||.|:    .|..|....:|.:..||..||.||:.||::||:|.|:::.|||::||||||||.
 Frog    10 SSTNETM----MGSPYKTVEVVFIVIVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 70

  Fly   149 ADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYR 213
            ||..||..||.|:.:.|::||||:||:|||.||||||:.|||||:|||||||||||.||:||||.
 Frog    71 ADLIIGVFSMNLYTLYTVIGYWPIGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 135

  Fly   214 AKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQYITFGTALAAFY 278
            .:|||..|.:||.|||.:|.:||.|.|..|.:|.|.||||:.||||||. :|..:|||||:||||
 Frog   136 VRRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEGECYIQFF-SNAAVTFGTAIAAFY 199

  Fly   279 FPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHASGGLLAFAQVGGNDH 343
            .||.||..|||:|.|.:|.|      ::.|||
 Frog   200 LPVIIMTVLYWQISRASKSR------IKKGKK--------------------------------- 225

  Fly   344 DTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTCFGSIKEWCIAWWHSG 408
                    |::|:.:.:..:|
 Frog   226 --------EAAPNQDPISPSN-------------------------------------------- 238

  Fly   409 REDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDV 473
                                        :|..:                     |:|
 Frog   239 ----------------------------VQGKI---------------------VKP-------- 246

  Fly   474 SPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNASHNGNGAVNG---NG-AGN 534
                                                     ||||.:.|.:|..:|   || ..:
 Frog   247 -----------------------------------------NNNNVAANEDGLDHGKIQNGKVTS 270

  Fly   535 GSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSNA--ANGGGGGPGAG 597
            .|||     .|....:.         ..:.:|.||....::....:||:.:.  |:|....|...
 Frog   271 NSGI-----ENCVQAEG---------EEKEISNDSTSVSVVNTKDEGAAKDVPQASGSQANPKTE 321

  Fly   598 AAASASL-----SMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSLPLGRRMS 657
            .:....:     |.:|||:        :...||....|.|:                   ||...
 Frog   322 NSKLTCIRIVTKSPKGDCS--------NATGTTVEIVPGAN-------------------GRNGE 359

  Fly   658 HAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKAAKTLSAI 722
            ..|:        ::.:::.|                |..:...||...|:||    |..:|:.||
 Frog   360 DKQN--------IVARKIVK----------------MTKQPPKKKLPPSREK----KVTRTILAI 396

  Fly   723 LLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFRRTYVRIL 787
            ||:|||||||||::|||.  |.|:.|:|..:|...|.||||||||||.||||||.||::|:..:|
 Frog   397 LLAFIITWTPYNVMVLIN--TFCAVCVPNTVWTIGYWLCYINSTINPACYALCNTTFKKTFKHLL 459

  Fly   788 TCKW 791
            .|::
 Frog   460 MCQY 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	117/194 (60%)
		TM helix 1	106..132	CDD:320428	12/25 (48%)
		TM helix 2	139..165	CDD:320428	15/25 (60%)
		TM helix 3	177..207	CDD:320428	24/29 (83%)
		TM helix 4	219..242	CDD:320428	11/22 (50%)
		TM helix 5	265..294	CDD:320428	18/28 (64%)
		7tm_GPCRs	<707..783	CDD:475119	44/75 (59%)
		TM helix 6	716..738	CDD:410628	14/21 (67%)
		TM helix 7	751..776	CDD:410628	16/24 (67%)
chrm2	XP_002942846.2	7tmA_mAChR_M2	27..455	CDD:320424	207/688 (30%)
		TM helix 1	28..54	CDD:320424	12/25 (48%)
		TM helix 2	61..87	CDD:320424	15/25 (60%)
		TM helix 3	99..129	CDD:320424	24/29 (83%)
		TM helix 4	141..164	CDD:320424	11/22 (50%)
		TM helix 5	186..215	CDD:320424	18/28 (64%)
		TM helix 6	384..414	CDD:320424	20/33 (61%)
		TM helix 7	423..448	CDD:320424	16/24 (67%)