DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-A and chrm3b

DIOPT Version :9

Sequence 1:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_001919160.1	Gene:	chrm3b / 100149598	ZFINID:	ZDB-GENE-090410-5	Length:	494	Species:	Danio rerio

Alignment Length:	794	Identity:	231/794 - (29%)
Similarity:	311/794 - (39%)	Gaps:	328/794 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MSLALAAHGPPSILEP-LFKTVTTSTTTTTTTTTSTTTTTASPAGYSPGYPGTTLLTALFENLTS 68
            |:|.|:|       || ||.| .:|........|:..:....||..|            ..|:|.
Zfish     1 MNLTLSA-------EPGLFLT-NSSPGMRANPVTAFMSHDLHPANDS------------LHNITQ 45

  Fly    69 TAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDK 133
             ..|.|.||..|                  :|:..:|::..:...:|.:|:.||.:|::|||::|
Zfish    46 -IPSVLSDPLGG------------------HSVLQVVMIALLCGSISLLTIIGNTLVLLSFKLNK 91

  Fly   134 QLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLII 198
            ||:|::||:|.|||.||..||.:||.|:....|:..|.||...||.|||:||:||||||:|||:|
Zfish    92 QLKTVNNYYLLSLAFADLIIGVLSMNLYTTYIIMDQWALGNFACDLWLAIDYVASNASVMNLLVI 156

  Fly   199 SFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIE 263
            ||||||||||||||||||||.||..|||.||.||.:||.|.|..|.|..|:|||..|:||||||
Zfish   157 SFDRYFSVTRPLTYRAKRTTKRAMTMIGLAWSISFILWAPAILFWQYFVGERTVEPDKCYIQFI- 220

  Fly   264 TNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDLPNLQAGKKDSSKRSNSSDENTVVNHA 328
            :....||.||:||||.|||||..|||||::||:.|.::|..|:|.       .|..:|:.||
Zfish   221 SEPITTFCTAIAAFYLPVTIMTVLYWRIYKETENRSRELAGLKAS-------GNVEEESVVV--- 275

  Fly   329 SGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKKSYTC 393
                  ..|.|.:        ||.||.:.:..                  :.::.|.|.:.
Zfish   276 ------VPQTGSS--------RSHSSYELQPA------------------APMRKTKTRRL---- 304

  Fly   394 FGSIKEWCIAWWHSG---REDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYS 455
                  |   :|..|   |..||.:
Zfish   305 ------W---FWSRGDVERSSSDSW---------------------------------------- 320

  Fly   456 MGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNAS 520
                                                                      |||..|
Zfish   321 ----------------------------------------------------------NNNETA- 326

  Fly   521 HNGNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPVINRINSRSVSQDSVYTILIRLPSDGASSN 585
                             |.:..:.:....|:                :.:|||
Zfish   327 -----------------ISIDQSDDDEEEDA----------------EHIYTI------------ 346

  Fly   586 AANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLASAAATRRPLPSRDSEFSL 650
                                                               .::.|.::.|:|.:
Zfish   347 ---------------------------------------------------EKQDLEAKPSKFGV 360

  Fly   651 PLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAAKKKKKSQEKRQESKA 715
                      ..:..|::|..|                    :.:||...|:||.|..|  |.||
Zfish   361 ----------SKSSTLDSKDQP--------------------VKSARKTNKRKKLSLVK--EKKA 393

  Fly   716 AKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYINSTINPMCYALCNATFR 780
            |:|||||||:||||||||||:||:...  |..|||..||...|.|||:|||:|||||||||..||
Zfish   394 AQTLSAILLAFIITWTPYNIMVLLNAF--CDGCIPETLWALGYWLCYVNSTVNPMCYALCNKAFR 456

  Fly   781 RTYVRILTCKWHTR 794
            .|:..||.|:|..:
Zfish   457 TTFRSILLCQWRKK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	77/123 (63%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	114/192 (59%)
chrm3b	XP_001919160.1	7tm_4	72..>244	CDD:304433	105/172 (61%)
chrm3b	XP_001919160.1	7tm_1	79..448	CDD:278431	193/653 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I1022
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1990
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1245472at2759
OrthoFinder	1	1.000	-	-		FOG0001308
OrthoInspector	1	1.000	-	-		otm24829
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X324
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.070