DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bs and BORCS8-MEF2B

DIOPT Version :9

Sequence 1:	NP_001286837.1	Gene:	bs / 37890	FlyBaseID:	FBgn0004101	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_005910.1	Gene:	BORCS8-MEF2B / 4207	HGNCID:	39979	Length:	365	Species:	Homo sapiens

Alignment Length:	247	Identity:	58/247 - (23%)
Similarity:	95/247 - (38%)	Gaps:	62/247 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMI 230
            ||.||::..|.::..|..||:|||.|:||||||||.|...::.|::.:....::.:|:..:..::
Human     2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVL 66

  Fly   231 ----------TSEAGKQLIQTC------LNSPD------PPSVG---------GGDQRM------ 258
                      .|.....:::|.      |:.|:      |...|         |||..:
Human    67 LKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLY 131

  Fly   259 -SATGFEETELSYNIADEDSKDDRSPTSSGNESDDSSDVEMPAEAAEVATKLPASKTEVSAPPAA 322
             :|......::.|........|   |:..|.        .:||::.....:..|.|   :.||..
Human   132 PAAPAMPSPDVVYGALPPPGCD---PSGLGE--------ALPAQSRPSPFRPAAPK---AGPPGL 182

  Fly   323 -----SCSAATASSGHKTMPALNYQTDTNSGPSTSTAAG-GGGSADSKYVYS 368
                 |.|..|:    ||.|.|...|:..........|| .||...|:.:||
Human   183 VHPLFSPSHLTS----KTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYS 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bs	NP_001286837.1	MADS_SRF_like	166..247	CDD:238166	26/96 (27%)
BORCS8-MEF2B	NP_005910.1	MADS_MEF2_like	2..78	CDD:238165	23/75 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..124		7/29 (24%)
		Atrophin-1	<123..364	CDD:331285	26/126 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..309		25/107 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810