DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bs and Srf

DIOPT Version :9

Sequence 1:	NP_001286837.1	Gene:	bs / 37890	FlyBaseID:	FBgn0004101	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_065239.1	Gene:	Srf / 20807	MGIID:	106658	Length:	504	Species:	Mus musculus

Alignment Length:	464	Identity:	176/464 - (37%)
Similarity:	220/464 - (47%)	Gaps:	107/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GNPALGAG-RPPSGGLLQNMGGVPPMQRPNPAAGAPPAPQCQTLHSPQHASQQQQQQQQQQQQHQ 94
            |.|..|.| |..:||.:...|......|....|.|..||....|:|......:..::::.
Mouse    28 GRPGGGGGTRGANGGRVPGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEEL----- 87

  Fly    95 QQQQQQQQHPQQQRGLKRSGSDCYEDHHRSSGGLTLQGLDNVASGAVDDSVDNYNPLPNKKSPPA 159
                     ..::||||||.|:       ...|:.:.|.:..|:.|     ..|.|:....|...
Mouse    88 ---------GAERRGLKRSLSE-------MELGVVVGGPEAAAAAA-----GGYGPVSGAVSGAK 131

  Fly   160 NGKKTKGRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATR 224
            .||||:||||||||:|||||||||||||||||||||||||||||||||:||||||||||||||||
Mouse   132 PGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATR 196

  Fly   225 KLQPMITSEAGKQLIQTCLNSPDPP--SVGGGDQRMSATGFEETELSYNIADEDS----KDDRSP 283
            |||||||||.||.||||||||||.|  |....|||||||||||.:|:|.:::.||    ||...|
Mouse   197 KLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKP 261

  Fly   284 T-SSGNESDDSSDVEMPAEAAEVATKLPASK------TEVSAPPAASCSAATASSGHKTMPALNY 341
            . :..|....:|.::   .|...:|.:..|.      |...||.:||.|.:..||.:.|:
Mouse   262 AFTVTNLPGTTSTIQ---TAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTV----- 318

  Fly   342 QTDTNSGPSTSTAAGG------------GGSADSKYVYSAASIANIPQKM---------LRQLIQ 385
            ...|.|||.:|   ||            ||:...:....|..:...||:.         |.|...
Mouse   319 LKSTGSGPVSS---GGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSS 380

  Fly   386 SGHLQVHAEEDGNQYVTIPLSSTAANLIKSNKLTASGSG-----------ASGSGTPVKNDASAD 439
            ||            .||:|     |.::.|:..|..|..           |..||.       ||
Mouse   381 SG------------TVTLP-----ATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGL-------AD 421

  Fly   440 KPLTIKQEF 448
            ..||:...|
Mouse   422 GSLTVLNAF 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bs	NP_001286837.1	MADS_SRF_like	166..247	CDD:238166	76/80 (95%)
Srf	NP_065239.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		16/79 (20%)
		MADS_SRF_like	138..219	CDD:238166	76/80 (95%)
		Involved in dimerization. /evidence=ECO:0000250	164..218		50/53 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..288		29/75 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..381		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7506
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3542
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S1695
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004046
OrthoInspector	1	1.000	-	-		oto95161
orthoMCL	1	0.900	-	-		OOG6_103066
Panther	1	1.100	-	-	LDO	PTHR48019
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R683
SonicParanoid	1	1.000	-	-		X3888
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.800