DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bs and Mef2d

DIOPT Version :9

Sequence 1:	NP_001286837.1	Gene:	bs / 37890	FlyBaseID:	FBgn0004101	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001297516.1	Gene:	Mef2d / 17261	MGIID:	99533	Length:	514	Species:	Mus musculus

Alignment Length:	337	Identity:	78/337 - (23%)
Similarity:	119/337 - (35%)	Gaps:	92/337 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMI 230
            ||.||:::.|.::..|..||:|||.|:||||||||.|...::.|::.:.:..::.:|:..:..::
Mouse     2 GRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVL 66

  Fly   231 ----------TSEAGKQLIQTC----LNSPDPPSVGGGDQRMSATGFEETELSYNIADEDSKDDR 281
                      .|.....:|:|.    .|..|.|...|.|      ..|::.|.     ||.....
Mouse    67 LKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGED------SLEQSPLL-----EDKYRRA 120

  Fly   282 SPTSSGNESDDSSDVEMPAEAAEVATKLP-ASKTEVSAPPAASCSAATASSG-------HKTMPA 338
            |....|......|.|..|..|..|...:. .|..:.|.|.::..:.:..:|.       ....||
Mouse   121 SEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPSSSLVTPSLVTSSLTDPRLLSPQQPA 185

  Fly   339 LNYQTDTNSGPSTSTAAGG--GGSADSK-----------YVYSAAS-----IAN-------IPQK 378
            |...:.:...|....:||.  ||..:|.           ||.:.||     :||       ||.|
Mouse   186 LQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVANGNSLNKVIPAK 250

  Fly   379 M------------------LRQLIQSG--HLQVHAEED--------------GNQYVTIPLSSTA 409
            .                  ||.:...|  .|..|..||              ....:|.|:.|.|
Mouse   251 SPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLTEDHLDLNNAQRLGVSQSTHSLTTPVVSVA 315

  Fly   410 ANLIKSNKLTAS 421
            ...:.|..|..|
Mouse   316 TPSLLSQGLPFS 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bs	NP_001286837.1	MADS_SRF_like	166..247	CDD:238166	27/94 (29%)
Mef2d	NP_001297516.1	MADS_MEF2_like	2..78	CDD:238165	23/75 (31%)
		HJURP_C	97..151	CDD:372061	15/64 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..207		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..269		3/24 (13%)
		Beta domain. /evidence=ECO:0000250	286..292		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5068
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810