DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slbo and Cebpb

DIOPT Version :9

Sequence 1:	NP_001286836.1	Gene:	slbo / 37889	FlyBaseID:	FBgn0005638	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_077039.3	Gene:	Cebpb / 24253	RGDID:	2327	Length:	297	Species:	Rattus norvegicus

Alignment Length:	279	Identity:	69/279 - (24%)
Similarity:	98/279 - (35%)	Gaps:	86/279 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 SDMVTSPGGLSATLPPSGMVSAAAKVLQQQTLRNQHGYGGRGGGGGAGGALAYMPQPVHATYNNS 217
            ||:.....|...:..||                 .:||...|..|......|..|.|..|
  Rat    89 SDLFADDYGAKPSKKPS-----------------DYGYVSLGRAGAKAAPPACFPPPPPA----- 131

  Fly   218 SDENSSVGSDSSTIKEEP-IDPEYRRHLQEAASQQAAFMGNGAGLYNGYGSGANGLTGGGNPLNG 281
                        .:|.|| .:|...:...:|.:..|.| ......|.||
  Rat   132 ------------ALKAEPGFEPADCKRADDAPAMAAGF-PFALRAYLGY---------------- 167

  Fly   282 GNTTPSSNGSNGSTGSSNGSQFT----NLTTANVLAHHNLPHLAAAAGAHNLLKQHSKLHAQQQH 342
             ..|||.:..:.||.||:....|    :...|........|...|.|.|
  Rat   168 -QATPSGSSGSLSTSSSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKA---------------- 215

  Fly   343 QQHQQQQQHRKHSNKHVDKGTDEYRRRRERNNIAVRKSREKAKVRSREVEERVKSLLKEKDALIR 407
                         .|.|||.:|||:.|||||||||||||:|||:|:.|.:.:|..|..|.:.|.:
  Rat   216 -------------KKAVDKLSDEYKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQK 267

  Fly   408 QLGEMTNELQLHKQIYMQL 426
            ::.:::.||...:.::.||
  Rat   268 KVEQLSRELSTLRNLFKQL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slbo	NP_001286836.1	bZIP_CEBP	362..420	CDD:269841	27/57 (47%)
slbo	NP_001286836.1	coiled coil	363..420	CDD:269841	27/56 (48%)
Cebpb	NP_077039.3	Required for Lys-134 sumoylation. /evidence=ECO:0000250\|UniProtKB:P17676	1..22
		Required for MYC transcriptional repression. /evidence=ECO:0000250\|UniProtKB:P28033	22..105		3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..201		7/28 (25%)
		bZIP_CEBPB	219..286	CDD:269860	30/66 (45%)
		coiled coil	226..277	CDD:269860	24/50 (48%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	227..247		16/19 (84%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	249..256		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339749
Domainoid	1	1.000	57	1.000	Domainoid score	I10594
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002856
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23334
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030