DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slbo and CEBPD

DIOPT Version :9

Sequence 1:	NP_001286836.1	Gene:	slbo / 37889	FlyBaseID:	FBgn0005638	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_005186.2	Gene:	CEBPD / 1052	HGNCID:	1835	Length:	269	Species:	Homo sapiens

Alignment Length:	254	Identity:	66/254 - (25%)
Similarity:	106/254 - (41%)	Gaps:	43/254 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 GYGGRGGGGGAGGALAYMPQPVHATYNNSSDENSSVGSDSSTIKEEPIDPEYRRHLQEAASQQAA 253
            |..|:.|.|...|||........|.|    |:.|::              ::..::...|:....
Human    28 GRAGKPGRGAEPGALGEPGAAAPAMY----DDESAI--------------DFSAYIDSMAAVPTL 74

  Fly   254 FMGNG---AGLYNGYGSGANGLTGGGNPLN---GGNTTPSSNG----------SNGSTGSSNGSQ 302
            .:.:.   |.|:|     :|...||..||.   ||...|...|          .:...|.:.||
Human    75 ELCHDELFADLFN-----SNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGS- 133

  Fly   303 FTNLTTANVLAHHNLPHLAAAAGAHNLLKQHSKLHAQQQHQQHQQQQQHRKHSNKHVDKGTDEYR 367
               |..|.|.|........||||............:..:........:.:....:..|:|:.|||
Human   134 ---LLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYR 195

  Fly   368 RRRERNNIAVRKSREKAKVRSREVEERVKSLLKEKDALIRQLGEMTNELQLHKQIYMQL 426
            :|||||||||||||:|||.|::|:::::..|..|.:.|.:::.::|.:|...:|.:.||
Human   196 QRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQL 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slbo	NP_001286836.1	bZIP_CEBP	362..420	CDD:269841	27/57 (47%)
slbo	NP_001286836.1	coiled coil	363..420	CDD:269841	26/56 (46%)
CEBPD	NP_005186.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..133		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..219		25/67 (37%)
		bZIP_CEBPD	188..252	CDD:269862	29/63 (46%)
		coiled coil	191..249	CDD:269862	26/57 (46%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	195..222		19/26 (73%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	226..254		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146011
Domainoid	1	1.000	56	1.000	Domainoid score	I10990
eggNOG	1	0.900	-	-		E1_KOG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I5346
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41584
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23334
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4506
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.920