DRSC/TRiP Functional Genomics Resources

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Protein Alignment NHLRC1 and trim2b

DIOPT Version :9

Sequence 1:NP_940988.2 Gene:NHLRC1 / 378884 HGNCID:21576 Length:395 Species:Homo sapiens
Sequence 2:XP_009304581.1 Gene:trim2b / 558046 ZFINID:ZDB-GENE-090312-70 Length:669 Species:Danio rerio


Alignment Length:223 Identity:53/223 - (23%)
Similarity:87/223 - (39%) Gaps:67/223 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   122 GWGTLVNPTGLALCPKTGRVVVVHDGRRRVKIFDSGGGCAHQFGEKGDAAQDIRYPVDVTITNDC 186
            |.|.|:.|.|::: .:.|.|:||.:....|.||...|....:||.:|:..:....|....:.|:.
Zfish   496 GSGRLMGPKGVSV-DQNGHVIVVDNKACTVFIFQPSGKLITKFGSRGNGDRQFAGPHFAAVNNNN 559

Human   187 HVVVTDAGDRSIKVFDFFGQIKLVIG------GQFSLPWGVETTPQNGIVVTDAEAGSLHLLDVD 245
            .:::||..:.|:|||:..|:..|..|      |||:.|.||.......|:|.|            
Zfish   560 EIIITDFHNHSVKVFNADGEFLLKFGSNGEGNGQFNAPTGVAVDVNGNIIVAD------------ 612

Human   246 FAEGVLRRTERLQAHLCNPRGVAVSWLTGAIAVLEHPLALGTGVCSTRVKVFSSSMQLVGQVDTF 310
                                     |                  .::|::||..|...:..::|.
Zfish   613 -------------------------W------------------GNSRIQVFDGSGSFLSYINTA 634

Human   311 GLSLYFPSKITASAVTFDHQGNVIVADT 338
            ...||.|..:   |:|.|  |:|:|||:
Zfish   635 ADPLYGPQGL---ALTSD--GHVVVADS 657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NHLRC1NP_940988.2 RING-HC_malin 25..72 CDD:319430
RING-HC finger (C3HC4-type) 26..71 CDD:319430
HemN 53..>133 CDD:333012 5/10 (50%)
NHL 1 113..157 12/34 (35%)
NHL_TRIM32_like 118..391 CDD:271331 53/223 (24%)
NHL repeat 129..169 CDD:271331 12/39 (31%)
NHL 2 161..204 11/42 (26%)
NHL repeat 177..216 CDD:271331 13/44 (30%)
NHL 3 205..245 12/45 (27%)
NHL repeat 218..259 CDD:271331 6/40 (15%)
NHL 4 248..300 4/51 (8%)
NHL repeat 261..313 CDD:271331 6/51 (12%)
NHL 5 301..349 12/38 (32%)
NHL repeat 321..353 CDD:271331 8/18 (44%)
NHL 6 350..393
NHL repeat 364..390 CDD:271331
trim2bXP_009304581.1 zf-B_box 29..66 CDD:279037
iSH2_PI3K_IA_R 73..199 CDD:304922
IG_FLMN 237..334 CDD:214720
Filamin 237..329 CDD:279024
NHL_TRIM2_like 396..669 CDD:271330 53/223 (24%)
NHL repeat 414..453 CDD:271330
YncE 415..>660 CDD:225926 53/223 (24%)
NHL repeat 461..500 CDD:271330 2/3 (67%)
NHL repeat 503..540 CDD:271330 12/37 (32%)
NHL repeat 547..588 CDD:271330 11/40 (28%)
NHL repeat 594..636 CDD:271330 13/96 (14%)
NHL repeat 639..665 CDD:271330 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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