DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaTub60D and AgaP_AGAP004914

DIOPT Version :9

Sequence 1:	NP_523842.2	Gene:	betaTub60D / 37888	FlyBaseID:	FBgn0003888	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	XP_315005.3	Gene:	AgaP_AGAP004914 / 1275720	VectorBaseID:	AGAP004914	Length:	441	Species:	Anopheles gambiae

Alignment Length:	445	Identity:	242/445 - (54%)
Similarity:	328/445 - (73%)	Gaps:	8/445 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREIVNLQAGQCGNQIGAKFWEIISEEHGIDSNGIYVGDSDLQLERVSVYYNEASAVTRSSGGKY 65
            |||||....|||||::...|||.|.:||.:::.|.:.|...|.|:|::||::|:...      .:
Mosquito     1 MREIVVFHLGQCGNRVAENFWEYICDEHCLNTEGQFEGQHYLPLQRINVYFDESPCC------NF 59

  Fly    66 VPRAILLDLEPGTMESVRSGPYGQLFRPDNFVYGQSGAGNNWAKGHYTEGAELVDNVLDVVRKEC 130
            |||:|..||||.|:..:|...||.||.|::|:.|::.||||||:|::||||||:|.:.|..|:..
Mosquito    60 VPRSIFADLEPSTLNYLRCSRYGSLFSPESFISGKTSAGNNWARGYHTEGAELLDQIEDCTRRMV 124

  Fly   131 ENCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSI 195
            |.|||||||||.||:|||||||:||||:..:::.:|.:|.||:||:||||||:.|||||||..::
Mosquito   125 EGCDCLQGFQLVHSIGGGTGSGLGTLLLENLKDHFPGKITNTFSVIPSPKVSEVVVEPYNAVFAL 189

  Fly   196 HQLVENTDETYCIDNEALYDICFRTLKVSNPSYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLA 260
            ..::.::|||:|:|||||||||..||::..|...|||||::..|:|:|...|:|||||:|||||.
Mosquito   190 SSMIRSSDETFCLDNEALYDICVNTLRLPVPDLDDLNHLIASAMAGITCSFRYPGQLNSDLRKLL 254

  Fly   261 VNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRG 325
            .||||:.|||||:||.|||.:|.|:.||..|||||..|:|...|:||||||:.|.:||.||:|||
Mosquito   255 TNMVPYRRLHFFVPGLAPLCARDSECYRQTTVPELVYQLFSTNNLMAACDPQLGTFLTAAAIFRG 319

  Fly   326 RMSMKEVDEQMLAVQNKNSSYFVEWIPNNVKTAVCDIPPKGLKMSSTFIGNTTAIQELFKRISEQ 390
            |:|.:.|:|.|.:|:.||...|..:||||||:|:||:||:|:||::|||.|||:|.:||:||:.|
Mosquito   320 RLSTRTVEEHMGSVRLKNELSFSNFIPNNVKSAICDVPPRGMKMAATFIANTTSITQLFRRITGQ 384

  Fly   391 FSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQE--ATADDEFDPE 443
            |..|||::|||||||||||||.||||.|..:.|||.||..|:|  .|.||..|.:
Mosquito   385 FGTMFRQRAFLHWYTGEGMDEAEFTEMEKGLADLVEEYDSYKEEGRTKDDVEDDD 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaTub60D	NP_523842.2	PLN00220	1..450	CDD:215107	242/445 (54%)
betaTub60D	NP_523842.2	beta_tubulin	2..432	CDD:276956	235/429 (55%)
AgaP_AGAP004914	XP_315005.3	PTZ00010	1..427	CDD:240228	237/431 (55%)
AgaP_AGAP004914	XP_315005.3	beta_tubulin	2..425	CDD:276956	235/428 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D962471at2759
OrthoFinder	1	1.000	-	-		FOG0000096
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820