DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fatp3 and acsl3a

DIOPT Version :9

Sequence 1:	NP_726437.2	Gene:	Fatp3 / 37887	FlyBaseID:	FBgn0034999	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001038593.1	Gene:	acsl3a / 567157	ZFINID:	ZDB-GENE-050420-181	Length:	713	Species:	Danio rerio

Alignment Length:	772	Identity:	171/772 - (22%)
Similarity:	273/772 - (35%)	Gaps:	232/772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LNLKQKLATRLGTILLATVIFGAFCWDNALASLTLGAVVALLLRNPTFVFALVMTASRDLKA--- 94
            :.|.|.|:..:      .::|....|..:|.|.    :..||||:|.  ...:...||.|||
Zfish     1 MRLTQDLSPAV------VLVFRLVVWLYSLISY----LPYLLLRSPE--SQSLSECSRRLKARSV 53

  Fly    95 -------FQRFVALNIYLLRKDRGGFTVARCFQDQARRRPKKTCF-----------VMDD----- 136
                   ::...||....:....|..|:.:.||......|...|.           ..:|
Zfish    54 SGDPAGPYRDVAALKGLEMCLHPGINTLDQVFQSSVSHFPNSDCLGTRELLSEEDETQEDGKVFK 118

  Fly   137 -------RHLSFAEALEFSQKIAGYFSDRGLERGDCVALLMETRLEYPCIWLGLSQ------LGV 188
                   |.:|:.:..:.........:..|.:....:|:..|||.|    |:..:|      ..:
Zfish   119 KVILGEYRWMSYEQVFKEVNAFGSGLAALGQKPMKNIAIFCETRAE----WIIAAQACFMYNFPL 179

  Fly   189 ITALINSNLRGESLLHSIKVANAKALIVGSELLDVLVSLREKEQLDEVPIYQY---TDDEV---- 246
            :|  :.|.|.|.::.|.:..|....:|...:||:.    :.|....|||...:   .||::
Zfish   180 VT--LYSTLGGPAIAHGLNEAEVSHIITSKDLLET----KLKSIFIEVPRLCHVIVVDDKLSTSS 238

  Fly   247 ---RGVAGHDLLPGAVDLVTALKTQKKLELPSAVCPGEARSKLLYVYTSGTTGLPKAAVITNLRF 308
               ||::.|. :....:|....:...|.:.|.  |..:.   .:.:||||:||:||..:|::...
Zfish   239 EYPRGISIHS-MASVKELGARPENASKPKNPP--CSSDV---AVIMYTSGSTGVPKGVMISHSNI 297

  Fly   309 LFMSAGSYYML-KMSSDDVVYDPLPLYHTA-----------GGIVGVGN---------AILNGS- 351
            :....|..:.: |:..||.....|||.|..           |..:|..:         .|..||
Zfish   298 ISGITGMTHRIPKLVEDDTYIGYLPLAHVLELSAEMVCLAHGCRIGYSSPQTLSDQSTKIKKGSR 362

  Fly   352 --TVVLRKKFSA----------RNFWLDCDRHNCTVAQYIG-ELCRYLLATSYSPDQQK------ 397
              ..|||....|          :|..|       .|.|..| :...:|||.:|..:|..
Zfish   363 GDISVLRPTLMAAVPEIMDRIYKNVML-------RVEQMSGFQRTLFLLAYNYKMEQLAMGYSTP 420

  Fly   398 -------HNLRLMYGNGLRPQI-----WSQFVRR-----FGIPHIGEIYGATE--GNSNLINI-- 441
                   ..:|.:.|..||..:     .|...:|     |..| :|:.||.||  |...:.::
Zfish   421 LCDKLVFRKVRALLGGRLRVLLSGGAPLSAATQRFMNICFCCP-VGQGYGLTETCGAGTISHLWD 484

  Fly   442 --TNRVGAIGFVPVYGSSLYPVQVLRCDEYTGELLKD--SKGH---CIRCQPGQAGLLVGKVDAR 499
              |.||||               .|.|.|..   |||  ..|:   .:.|..|:  :|||
Zfish   485 YSTGRVGA---------------PLVCCELQ---LKDWIEGGYHSTDLPCPRGE--ILVG----- 524

  Fly   500 RAVSAFHGY---ADKGASE---QKLLRNVFTSGDVFFNSGDMVVRDILGYFYFKDRTGDTFRWR- 557
             ..|...||   ..|.:.:   .|..:..|.:||:....||..::.|       ||..|..:.:
Zfish   525 -GPSITMGYYKNTHKTSEDFFVDKKGQRWFCTGDIGEIHGDGCLKII-------DRKKDLVKLQA 581

  Fly   558 GENVATQEVEAIITNC---------VGLEDCVVYGVQIPHVEGKAGMAAIVDPERK--------- 604
            ||.|:..:|||.:.||         ...::..|.|..:|:.:....:|     |||
Zfish   582 GEYVSLGKVEAALKNCPLVDNICAYANSDESYVIGFVVPNQKQLLALA-----ERKRVRGLWEEL 641

  Fly   605 -----VDMDYLSVV----LRGSLPPYARPLFIRLLDE--IPRTA----TFKLKKREL 646
                 ::...|:|:    |...|..:..|..|||..|  .|.|.    :||||::||
Zfish   642 CNNPVIEEAVLTVLTEAALTAQLERFEIPRKIRLSVEPWTPDTGLVTDSFKLKRKEL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	PRK08279	90..684	CDD:236217	158/715 (22%)
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:213305	146/648 (23%)
acsl3a	NP_001038593.1	PLN02387	77..710	CDD:215217	152/684 (22%)
acsl3a	NP_001038593.1	LC-FACS_euk	123..710	CDD:213293	145/638 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930