DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fatp3 and Slc27a2

DIOPT Version :9

Sequence 1:	NP_726437.2	Gene:	Fatp3 / 37887	FlyBaseID:	FBgn0034999	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_036108.2	Gene:	Slc27a2 / 26458	MGIID:	1347099	Length:	620	Species:	Mus musculus

Alignment Length:	628	Identity:	232/628 - (36%)
Similarity:	342/628 - (54%)	Gaps:	58/628 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LASLTLGAVVALLLRNPTFVFALVMTASRDLKAFQRF--VALNIYLLRKDRGGFTVARCFQDQAR 124
            |..|..|....|||  |..:........:|::.|.|.  :|..:...|:.|...|:.|.|.:|||
Mouse     2 LPVLYTGLAGLLLL--PLLLTCCCPYLLQDVRYFLRLANMARRVRSYRQRRPVRTILRAFLEQAR 64

  Fly   125 RRPKKTCFVMDDRHLSFAEALEFSQKIAGYFSDR-GLERGDCVALLMETRLEYPCIWLGLSQLGV 188
            :.|.|...:..|..|::|:....|.::|....|: ||.:||||||.|.....|..|||||.:||.
Mouse    65 KTPHKPFLLFRDETLTYAQVDRRSNQVARALHDQLGLRQGDCVALFMGNEPAYVWIWLGLLKLGC 129

  Fly   189 ITALINSNLRGESLLHSIKVANAKALIVGSELLDVLVSLREKEQLDEVPIYQYTDDEVRGVAGHD 253
            ..|.:|.|:|.:||||..:...||.|:...:|.:.:..:....:.|.|.::..:  ......|.|
Mouse   130 PMACLNYNIRAKSLLHCFQCCGAKVLLASPDLQEAVEEVLPTLKKDAVSVFYVS--RTSNTNGVD 192

  Fly   254 LLPGAVDLVTALKTQKKLELPSAVCPGEARSKL------LYVYTSGTTGLPKAAVITNLRF---- 308
            .:...||.|:|..|           |...||::      :|:||||||||||||.|.:.|.
Mouse   193 TILDKVDGVSAEPT-----------PESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGT 246

  Fly   309 -LFMSAGSYYMLKMSSDDVVYDPLPLYHTAGGIVGVGNAILNGSTVVLRKKFSARNFWLDCDRHN 372
             |.||:|      :::.||:|..:||||:|..::|:...|:.|:|:.||.||||..||.||.::|
Mouse   247 GLAMSSG------ITAQDVIYTTMPLYHSAALMIGLHGCIVVGATLALRSKFSASQFWDDCRKYN 305

  Fly   373 CTVAQYIGELCRYLLATSYSPDQQKHNLRLMYGNGLRPQIWSQFVRRFGIPHIGEIYGATEGNSN 437
            .||.||||||.|||..|...|:.:.|.::...|||||..:|.:|::|||..|:.|.|.:||||..
Mouse   306 VTVIQYIGELLRYLCNTPQKPNDRDHKVKKALGNGLRGDVWREFIKRFGDIHVYEFYASTEGNIG 370

  Fly   438 LINITNRVGAIGFVPVYGSSLYPVQVLRCDEYTGELLKDSKGHCIRCQPGQAGLLVGKVDARRAV 502
            .:|...::||:|........:...::::.|....|.::|:.|:||:...|:.||||.|:   ..:
Mouse   371 FVNYPRKIGAVGRANYLQRKVARYELIKYDVEKDEPVRDANGYCIKVPKGEVGLLVCKI---TQL 432

  Fly   503 SAFHGYA-DKGASEQKLLRNVFTSGDVFFNSGDMVVRDILGYFYFKDRTGDTFRWRGENVATQEV 566
            :.|.||| .|..:|:|.||:||..||::|||||:::.|...:.||.||.||||||:||||||.||
Mouse   433 TPFIGYAGGKTQTEKKKLRDVFKKGDIYFNSGDLLMIDRENFVYFHDRVGDTFRWKGENVATTEV 497

  Fly   567 EAIITNCVGLEDCV----VYGVQIPHVEGKAGMAAIVDPERKVDMDY------LSVVLRGSLPPY 621
            ..|    |||.|.|    ||||.:|..||:.|||::     |:..:|      |...:...||.|
Mouse   498 ADI----VGLVDFVEEVNVYGVPVPGHEGRIGMASL-----KIKENYEFNGKKLFQHIAEYLPSY 553

  Fly   622 ARPLFIRLLDEIPRTATFKLKKRELAKEAYDIGQLSDPIYYLN 664
            |||.|:|:.|.|..|.|||.:|..|.:|.::...:.|.:|:::
Mouse   554 ARPRFLRIQDTIEITGTFKHRKVTLMEEGFNPTVIKDTLYFMD 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	PRK08279	90..684	CDD:236217	225/600 (38%)
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:213305	209/539 (39%)
Slc27a2	NP_036108.2	hsFATP2a_ACSVL_like	74..610	CDD:341261	211/554 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1179
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740