DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fatp3 and Slc27a1

DIOPT Version :9

Sequence 1:	NP_726437.2	Gene:	Fatp3 / 37887	FlyBaseID:	FBgn0034999	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_006509734.1	Gene:	Slc27a1 / 26457	MGIID:	1347098	Length:	657	Species:	Mus musculus

Alignment Length:	615	Identity:	263/615 - (42%)
Similarity:	378/615 - (61%)	Gaps:	18/615 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 FVFALVMTASRDLKAFQRFVALNIYLLRKDRGGFTVARCFQDQARRRPKKTCFVMDDRHL--SFA 142
            |:..:..||.|||......:.:.:.|.|..|.|.|:...||..|||:|::...|.....:  :||
Mouse    54 FLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFA 118

  Fly   143 EALEFSQKIAGYFSDRGLERGDCVALLMETRLEYPCIWLGLSQLGVITALINSNLRGESLLHSIK 207
            :...:|..:|..|...|...||.||:.:|.|.|:..:||||::.||:.||:|.|||.|.|...:.
Mouse   119 QLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLG 183

  Fly   208 VANAKALIVGSELLDVLVSLREKEQLDEVPIYQYTDDEVRGVAGHDLLPGAVDLVTALKTQKKLE 272
            .:.|||||.|.|:...:..:  .|||.:         .:......||.|.::...|.|......|
Mouse   184 TSAAKALIYGGEMAAAVAEV--SEQLGK---------SLLKFCSGDLGPESILPDTQLLDPMLAE 237

  Fly   273 LPS---AVCPGEAR-SKLLYVYTSGTTGLPKAAVITNLRFLFMSAGSYYMLKMSSDDVVYDPLPL 333
            .|:   |..||:.. .:|.|:||||||||||||::.:.|:..::|..::...|.:.||:||.|||
Mouse   238 APTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPL 302

  Fly   334 YHTAGGIVGVGNAILNGSTVVLRKKFSARNFWLDCDRHNCTVAQYIGELCRYLLATSYSPDQQKH 398
            ||:||.|:|||..::.|.||||||||||..||.||.::||||.|||||:|||||.......:|:|
Mouse   303 YHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRH 367

  Fly   399 NLRLMYGNGLRPQIWSQFVRRFGIPHIGEIYGATEGNSNLINITNRVGAIGFVPVYGSSLYPVQV 463
            .:||..||||||.||.:|.:|||:|.|||.|||||.|.::.|:..:||:.||.....:.:||:::
Mouse   368 RVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRL 432

  Fly   464 LRCDEYTGELLKDSKGHCIRCQPGQAGLLVGKVDARRAVSAFHGYADKGASEQKLLRNVFTSGDV 528
            ::.:|.|.|.|:||:|.||.||||:.|||||:::.:..:..|.||....|:.:|:..:||..||.
Mouse   433 VKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDS 497

  Fly   529 FFNSGDMVVRDILGYFYFKDRTGDTFRWRGENVATQEVEAIITNCVGLEDCVVYGVQIPHVEGKA 593
            .:.|||::|.|.|||.||:||:|||||||||||:|.||||:::..:|..|..||||.:|.|||||
Mouse   498 AYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKA 562

  Fly   594 GMAAIVDPERKVDMDYLSVVLRGSLPPYARPLFIRLLDEIPRTATFKLKKRELAKEAYDIGQLSD 658
            |||||.||..::|.:.:...|:..|..||||:|:|||.::..|.|||::|..|.:|.:|..|.||
Mouse   563 GMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSD 627

  Fly   659 PIYYLN-RDGIYRPLSQEQHELLRSGKAGL 687
            .:::|: :.|.|.||.:..|..:.:|...|
Mouse   628 RLFFLDLKQGRYVPLDERVHARICAGDFSL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	PRK08279	90..684	CDD:236217	258/600 (43%)
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:213305	233/522 (45%)
Slc27a1	XP_006509734.1	AFD_class_I	115..622	CDD:418409	233/517 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1179
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63225
OrthoDB	1	1.010	-	-		D390277at33208
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2110
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750