DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fatp3 and Slc27a6

DIOPT Version :9

Sequence 1:	NP_726437.2	Gene:	Fatp3 / 37887	FlyBaseID:	FBgn0034999	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001074541.1	Gene:	Slc27a6 / 225579	MGIID:	3036230	Length:	619	Species:	Mus musculus

Alignment Length:	609	Identity:	232/609 - (38%)
Similarity:	355/609 - (58%)	Gaps:	37/609 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LKAFQRFVALNIYLLRKDRGGFTVARCFQDQARRRPKKTCFVMDDRHLSFAEALEFSQKIA-GYF 155
            ||..:..:.:.:|.||.:.  .||...|....|::|:|...:.:....::.:..:.|.:|| ...
Mouse    35 LKVVRYGIQMEMYKLRGEL--VTVLDKFLSHTRKQPRKAFIIYEGDVYTYEDVDKRSNRIAHALL 97

  Fly   156 SDRGLERGDCVALLMETRLEYPCIWLGLSQLGVITALINSNLRGESLLHSIKVANAKALIVGSEL 220
            :...|:|||.|||||....::..:|.||::||.:.|.:|||||.:||||.|......|::||.:|
Mouse    98 NHSSLKRGDVVALLMSNEPDFVHVWFGLAKLGCVVAFLNSNLRFDSLLHCINTCEPTAVVVGGDL 162

  Fly   221 LDVLVSLREKEQLDEVPIYQYTDDEVRGVAGHDLLPGAVDLVTALKTQKKLEL-------PSAVC 278
            |..:     :|.|..:|      ..||.....|.:|..:|     ..|:||.|       ||...
Mouse   163 LGSI-----EEILPSLP------KHVRVWGMKDSVPEGID-----SLQEKLSLASDEPVPPSHHV 211

  Fly   279 PGEARSKLLYVYTSGTTGLPKAAVITNLRFLFMSAGSYYMLKMSSDDVVYDPLPLYHTAGGIVGV 343
            ....:|..||::|||||||||||||:.|:.|..|.| .:....::||::|..|||||::|.::|:
Mouse   212 TSSLKSTCLYIFTSGTTGLPKAAVISQLQVLKGSVG-LWAFGCTADDIIYITLPLYHSSGSLLGI 275

  Fly   344 GNAILNGSTVVLRKKFSARNFWLDCDRHNCTVAQYIGELCRYLLATSYSPDQQKHNLRLMYGNGL 408
            |..:..|:|.||:|||||..||.||.::|.||.||||||||||........::.|.:||..||||
Mouse   276 GGCVELGATCVLKKKFSASQFWNDCKKYNVTVFQYIGELCRYLCKQPQREGEKDHRVRLAVGNGL 340

  Fly   409 RPQIWSQFVRRFGIPHIGEIYGATEGNSNLINITNRVGAIGFVPVYGSSLYPVQVLRCDEYTGEL 473
            ...:|.||:.|||...:.|:|||||||...:|.|.::|::|....:.|..:..::::.|....|.
Mouse   341 SSDVWRQFLDRFGNIKMCELYGATEGNIVFMNHTGKIGSVGRANFFYSLFFSFELIKYDFQKDEP 405

  Fly   474 LKDSKGHCIRCQPGQAGLLVGKVDARRAVSAFHGYADKGA-SEQKLLRNVFTSGDVFFNSGDMVV 537
            .::.:|.|...:.|:.|||:.:|:.:   :.|.|||.... ::.|||.:||..|||:||:||::.
Mouse   406 WRNGQGWCSCVRKGEPGLLISRVNKK---NPFFGYAGSDTHTKSKLLFDVFRKGDVYFNTGDLMF 467

  Fly   538 RDILGYFYFKDRTGDTFRWRGENVATQEVEAIITNCVGLEDCVVYGVQIPHVEGKAGMAAIV-DP 601
            :|...:.||.||.||||||:||||||.||..::.....:::..||||::|..||||||.::: .|
Mouse   468 QDQENFVYFWDRLGDTFRWKGENVATTEVADVLGRLDFIQEANVYGVRVPGYEGKAGMTSVILKP 532

  Fly   602 ERKVDMD--YLSVVLRGSLPPYARPLFIRLLDEIPRTATFKLKKRELAKEAYDIGQLSDPIYYL- 663
            .:.:|::  |..||.  |||.||.|||:|:.|::..|.||||||.:|.:|.:|..::|||:|::
Mouse   533 NKSLDLEKMYNQVVT--SLPAYACPLFLRIQDKMETTGTFKLKKLQLVEEGFDPLKISDPLYFMD 595

  Fly   664 NRDGIYRPLSQEQHELLRSGKAGL 687
            |....|.||::|.:..:.|.:..|
Mouse   596 NLKKSYVPLTEEIYNQIMSEEVKL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	PRK08279	90..684	CDD:236217	231/604 (38%)
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:213305	209/528 (40%)
Slc27a6	NP_001074541.1	AFD_class_I	75..609	CDD:418409	219/555 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1179
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000388
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100576
Panther	1	1.100	-	-	O	PTHR43107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2110
SonicParanoid	1	1.000	-	-		X222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.770