Protein Alignment Fatp3 and ACSL4

DIOPT Version :10

• Sequence 1: NP_726437.2
• Gene: Fatp3 / 37887
• FlyBaseID: FBgn0034999
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 131/627 - (20%)
• Similarity: 231/627 - (36%)
• Gaps: 184/627 - (29%)

  Fly   145 LEFSQKIAGYFSD---RGLERGDCVALLMETRLEYPCIWLGLSQ------LGVITALINSNLRGE 200
            ||.::::..:.|.   .||:..:.:|:..|||.|    |:..:|      ..::|  :.:.|..|
Human   129 LEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAE----WMIAAQTCFKYNFPLVT--LYATLGKE 187

  Fly   201 SLLHSIKVANAKALIVGSELLDVLVSLREKEQLDEVPIYQ---YTDDEVRGVAGHDLLPGAVDLV 262
            :::|.:..:.|..||...|||:    .:.|..|.::...:   |.|::....|.:   |...: :
Human   188 AVVHGLNESEASYLITSVELLE----SKLKTALLDISCVKHIIYVDNKAINKAEY---PEGFE-I 244

  Fly   263 TALKTQKKLEL--------PSAVCPGEARSKLLYVYTSGTTGLPKAAVITNLRFLFMSAGSYYML 319
            .::::.::|..        ||...|.:   ..:.:||||:||.||..::.:...:....|....:
Human   245 HSMQSVEELGSNPENLGIPPSRPTPSD---MAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERI 306

  Fly   320 K-MSSDDVVYDPLPLYH-----------TAGGIVGVGNAI-LNGSTVVLRKKFSARNFWLDC--- 368
            . :...|.....|||.|           |.|..:|..:.: |:..:..::|....     ||
Human   307 PGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKG-----DCTVL 366

  Fly   369 ------------DRHNCTVAQYIGELCRYLLAT------SYSPDQQKH----------------- 398
                        ||....|...:.|: .|:..|      .|..:|.|.
Human   367 KPTLMAAVPEIMDRIYKNVMSKVQEM-NYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKA 430

  Fly   399 ----NLRLMYGNG--LRPQIWSQFVRRFGIPHIGEIYGATE--GNSNLINITN----RVGAIGFV 451
                |:|:|...|  |.||........|..| ||:.||.||  |...:..:|:    ||||
Human   431 LLGGNVRMMLSGGAPLSPQTHRFMNVCFCCP-IGQGYGLTESCGAGTVTEVTDYTTGRVGA---- 490

  Fly   452 PVYGSSLYPVQVLRCDEYTGELLKD--SKGHCIRCQPGQAGLLVGKVDARRAVSAFHGYADKGAS 514
                       .|.|.|..   |||  ..|:.|..:|...|.:|  :..:.....:....:|.|.
Human   491 -----------PLICCEIK---LKDWQEGGYTINDKPNPRGEIV--IGGQNISMGYFKNEEKTAE 539

  Fly   515 EQKLLRNVFTSGDVFFNSGDMVVRDILGYFY------FKDRTGDTFRWR-GENVATQEVEAIITN 572
            :..:..|    |..:|.:||      :|.|:      ..||..|..:.: ||.|:..:|||.:.|
Human   540 DYSVDEN----GQRWFCTGD------IGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKN 594

  Fly   573 CVGLEDCVVYGVQIPHVEGKAGMAAIVDPERK-----------------------VDMDYLSVVL 614
            |..:::...:.     ...::.:.:.|.|.:|                       ::.:.|..:.
Human   595 CPLIDNICAFA-----KSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIR 654

  Fly   615 RGS----LPPYARPLFIRLLDE--IPRTA----TFKLKKREL 646
            ..:    |..:..|:.:||..|  .|.|.    .||||::||
Human   655 EAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKEL 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fatp3	NP_726437.2	hsFATP4_like	136..653	CDD:341262	131/627 (21%)
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	129/625 (21%)