Protein Alignment nvy and CBFA2T3

DIOPT Version :10

• Sequence 1: NP_001261166.1
• Gene: nvy / 37886
• FlyBaseID: FBgn0005636
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_005178.4
• Gene: CBFA2T3 / 863
• HGNCID: 1537
• Length: 653
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 213/730 - (29%)
• Similarity: 309/730 - (42%)
• Gaps: 186/730 - (25%)

  Fly    49 ASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTSSSRSERD 113
            ||.|:.||.|.......:...::|..:|....|....:....|:..|:.....:...:..||
Human    14 ASGSTCGSMSQTHPVLESGLLASAGCSAPRGPRKGGPAPVDRKAKASAMPDSPAEVKTQPRS--- 75

  Fly   114 RERERERERERDRLCRTPPD--SPPDSSRSLAPRSP-HSPLQLHQHPQRNASVSP---------- 165
                            |||.  .||.::...|.|.| .:|   |.|.:...:..|
Human    76 ----------------TPPSMPPPPPAASQGATRPPSFTP---HTHREDGPATLPHGRFHGCLKW 121

  Fly   166 -----VVNGSSSGGGGVGSSGTSPTPT-----PGSQHAASLAAAAAAAAAAHVEQARLVSKMRKF 220
                 ::||||.....:  :|...||.     |.:...|||:......|..    ||.:||:::|
Human   122 SMVCLLMNGSSHSPTAI--NGAPCTPNGFSNGPATSSTASLSTQHLPPACG----ARQLSKLKRF 180

  Fly   221 LGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQ 285
            |..|.||..:: .||:.||||.|||.|.:.::::|||...||||.|.||||:|:|.||.::.|:|
Human   181 LTTLQQFGSDI-SPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQ 244

  Fly   286 REILALARATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSM 350
            ||:|..||...|:..||:..:||.:::.:    ||:......:.||. ..||     |||:.|..
Human   245 RELLHCARLAKQTPAQYLAQHEQLLLDAS----ASSPIDSSELLLEV-NENG-----KRRTPDRT 299

  Fly   351 MEHGGHNG-------------LQEWNEYMASGGAGYP-PPPSKRL-TLHPAHSVVAYGEYGVSSA 400
            .|:|....             |.....|..|.|...| |||..|| .:..||..
Human   300 KENGSDRDPLHPEHLSKRPCTLNPAQRYSPSNGPPQPTPPPHYRLEDIAMAHHF----------- 353

  Fly   401 EGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAPGAGGE------------ 453
                 ..|:...|.|:||     .||            .|..    .||:..|
Human   354 -----RDAYRHPDPRELR-----ERH------------RPLV----VPGSRQEEVIDHKLTEREW 392

  Fly   454 -EEWKNIHTMLNCISAMVDKTKRAITILQ-----------------------QRGIEP--QHPNS 492
             ||||:::.:||||..||:||:|::|:|:                       ::|..|  ..|.|
Human   393 AEEWKHLNNLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWARRYSDAEDTKKGPAPAAARPRS 457

  Fly   493 GQEVTPAAMAELRRQ------TEEKVAEFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQ 551
            ..........::.|:      |.....:..|.||:||.:|||||:.|:|:||..||.:|.|::|.
Human   458 SSAGPEGPQLDVPREFLPRTLTGYVPEDIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITT 522

  Fly   552 ERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSAS 616
            ||.:||:...|..|.:|.:      :.::.:.|..|:  :.||||||||:|||||||.||||.:.
Human   523 ERAKMERALAEAKRQASED------ALTVINQQEDSS--ESCWNCGRKASETCSGCNAARYCGSF 579

  Fly   617 CQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPN--SAAHLQAAAAAAAAAA 679
            ||:|||:.||.|||.                 ||:...|..:.|.|.  .||| ....:....||
Human   580 CQHRDWEKHHHVCGQ-----------------SLQGPTAVVADPVPGPPEAAH-SLGPSLPVGAA 626

  Fly   680 GAREAVSAPVGGPGA 694
            ...||.||....||:
Human   627 SPSEAGSAGPSRPGS 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nvy	NP_001261166.1	TAFH	213..304	CDD:197785	43/90 (48%)
		NHR2	<454..>482	CDD:430219	15/50 (30%)
		zf-MYND	593..629	CDD:460312	26/35 (74%)
CBFA2T3	NP_005178.4	Interaction with ZBTB33. /evidence=ECO:0000269|PubMed:23251453	145..242		41/101 (41%)
		TAFH	173..262	CDD:462195	42/89 (47%)
		Interaction with HIF1A. /evidence=ECO:0000269|PubMed:25974097	176..268		43/92 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..342		18/63 (29%)
		NHR2	379..445	CDD:430219	16/65 (25%)
		Nervy homology region 2 (NHR2), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	394..412		10/17 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..472		4/37 (11%)
		vATP-synt_E	482..>553	CDD:419987	27/76 (36%)
		Nervy homology region 3 (NHR3), essential for down-regulation of PFKFB3, PFKFB4 and PDK1 expression. /evidence=ECO:0000269|PubMed:23840896	485..533		23/47 (49%)
		Mediates interaction with PRKAR2A. /evidence=ECO:0000269|PubMed:11823486	485..506		11/20 (55%)
		zf-MYND	556..592	CDD:460312	26/35 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..653		13/40 (33%)
		Mediates localization to the nucleus. /evidence=ECO:0000250	1..435		134/496 (27%)
		Mediates interaction with PDE7A (in isoform 2)	1..430		134/491 (27%)
		Required for nucleolar targeting (in isoform 1)	1..127		25/134 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..109		24/116 (21%)