DRSC/TRiP Functional Genomics Resources

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Protein Alignment nvy and Cbfa2t2

DIOPT Version :9

Sequence 1:NP_001261166.1 Gene:nvy / 37886 FlyBaseID:FBgn0005636 Length:757 Species:Drosophila melanogaster
Sequence 2:NP_766448.1 Gene:Cbfa2t2 / 12396 MGIID:1333833 Length:594 Species:Mus musculus


Alignment Length:631 Identity:183/631 - (29%)
Similarity:289/631 - (45%) Gaps:147/631 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 TPPDSPPDSSRSLAPRSPHSPLQLHQHPQRNASVSPVVNGSSSGGGGVGSSGTSPTPTPGSQHAA 194
            :||..||     |.|.:|..|        |..|.:|     ::...|:..|..:....|......
Mouse    35 SPPIMPP-----LPPINPGGP--------RPVSFTP-----TALSNGINHSPPTLNGAPSPPQRF 81

  Fly   195 SLAAAAAAAAAAHVEQ------ARLVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSIS 253
            |...|::.::|...:|      ||.:||:::||..|.||..:: .||:.|:||.|||:|.:.:::
Mouse    82 SNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDI-SPEIGEKVRTLVLALVNSTVT 145

  Fly   254 VEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALARATNQSALQYVTNNEQAVMEFAPHGV 318
            :|||...||||.|.||||:|:|.||.::.|:|||:|..|||..|:..||:..:|..::.      
Mouse   146 IEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLN------ 204

  Fly   319 ASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSMME-HGGHNGL----QEWNEYMASGGAGYPPPPS 378
                           ||..|.|    .||:.:|| ||  ||.    :..:|.........|.||:
Mouse   205 ---------------TSIASPA----DSSELLMEVHG--NGKRPSPERRDENNFERDTVPPEPPA 248

  Fly   379 KRL-TLHPA--HSVVAY-------GEYGVS-------SAEGLPSAAAFMQRDERDLRMSEAQARH 426
            ||: |:.||  ||....       |::..:       :.|.:.::..:.:.::. |...|.:.||
Mouse   249 KRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKM-LEHREVRERH 312

  Fly   427 AAPPQRAGNPQPNPNAAAPGAPGAGGE------------EEWKNIHTMLNCISAMVDKTKRAITI 479
                         .|.:..|  |...|            :|||::...||||..||:||:|::.:
Mouse   313 -------------HNLSLNG--GYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAV 362

  Fly   480 ------------------------LQQRGIE---PQH-PNSGQEVTPAAMAEL--RRQTEEKVAE 514
                                    |::.|.|   .|| |.|...::..:..|.  |..|.....|
Mouse   363 LRRCQESDREELNYWKRRFNENTELRKTGTELVSRQHSPGSTDSLSNDSQREFTSRPATGYVPVE 427

  Fly   515 FKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQERLRMEKFFMEMSRHSSGERDLDNKSPS 579
            |.:..|:||.:||.||:.|:|:||..||.:|.|::..||.|||:...::.|.::.:..|      
Mouse   428 FWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFL------ 486

  Fly   580 MASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSASCQYRDWDSHHQVCGNTRASELSAKHLHS 644
            :.:.|..|.  :.||||||||:|||||||:||||.:.||::||:.||::||.:    |.....||
Mouse   487 VINEQEEST--ENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQS----LHGHSPHS 545

  Fly   645 ASNLSL---RNAMATRSPPTPNSAAHLQAAAAAAAAAAGAREAVSA 687
            .|...|   |.:..:.....|:.|....:|..:.::...:..|:.|
Mouse   546 QSRPLLPGGRGSARSADCSVPSPALDKTSATTSRSSTPASVTAIDA 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nvyNP_001261166.1 TAFH 213..304 CDD:197785 43/90 (48%)
NHR2 <454..>482 CDD:285941 13/51 (25%)
zf-MYND 593..629 CDD:280009 25/35 (71%)
Cbfa2t2NP_766448.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 48..96 10/60 (17%)
Interaction with PRDM14. /evidence=ECO:0000269|PubMed:26523391, ECO:0000269|PubMed:27281218 98..206 46/129 (36%)
TAFH 106..192 CDD:311467 41/86 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..257 11/38 (29%)
NHR2 322..388 CDD:312356 13/65 (20%)
Nervy homology region 2 (NHR2). /evidence=ECO:0000250|UniProtKB:O43439 322..368 13/45 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..416 7/27 (26%)
Nervy homology region 3 (NHR3). /evidence=ECO:0000250|UniProtKB:O43439 426..475 22/48 (46%)
MutS_III <429..>497 CDD:331876 24/75 (32%)
zf-MYND 498..534 CDD:307734 25/35 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..594 11/54 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846903
Domainoid 1 1.000 89 1.000 Domainoid score I7820
eggNOG 1 0.900 - - E1_28KWJ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 227 1.000 Inparanoid score I3461
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50012
OrthoDB 1 1.010 - - D198762at33208
OrthoFinder 1 1.000 - - FOG0001881
OrthoInspector 1 1.000 - - otm44293
orthoMCL 1 0.900 - - OOG6_103448
Panther 1 1.100 - - O PTHR10379
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1413
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.770

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