Protein Alignment CG3376 and SMPD1

DIOPT Version :10

• Sequence 1: NP_001246491.1
• Gene: CG3376 / 37884
• FlyBaseID: FBgn0034997
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_000534.3
• Gene: SMPD1 / 6609
• HGNCID: 11120
• Length: 631
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 254/680 - (37%)
• Similarity: 362/680 - (53%)
• Gaps: 91/680 - (13%)

  Fly    50 GKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRT 114
            |..|:.|||...|       ||.........::.|.            |....| |.|..||.|.
Human    29 GLLWMGLVLALAL-------ALALALALSDSRVLWA------------PAEAHP-LSPQGHPARL 73

  Fly   115 HRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIEN 179
            ||          .:.||               .||.|...|..|
Human    74 HR----------IVPRL---------------RDVFGWGNLTCP--------------------- 92

  Fly   180 SVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVL 244
              :.|...||...|   |:.:....:..:..|::    |..|.|....|||.:..||..:::.|.
Human    93 --ICKGLFTAINLG---LKKEPNVARVGSVAIKL----CNLLKIAPPAVCQSIVHLFEDDMVEVW 148

  Fly   245 KRVNLSPDELCSFVIGDGCA--DVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDT 307
            :|..|||.|.|..::|..|.  |:::   .|.:..|.|||||..|..| |...||..::|.::|.
Human   149 RRSVLSPSEACGLLLGSTCGHWDIFS---SWNISLPTVPKPPPKPPSP-PAPGAPVSRILFLTDL 209

  Fly   308 HYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDID 372
            |:|..|.||::.||.:|||||..||.|......||.||:|.|||.|.||::.:||.:... ...|
Human   210 HWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPA-GPFD 273

  Fly   373 YILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPG-VPIFPALGNHESAPVNSFPPPYVNQV 436
            .:.||||:|.||||:||:::.|..: .||..:|..|.| ||::||:|||||.||||||||:: :.
Human   274 MVYWTGDIPAHDVWHQTRQDQLRAL-TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFI-EG 336

  Fly   437 DISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP 501
            :.|..|||:.:...|..|||.....|:|.|.||::...||.|:||||||:|:.:|:|||:|||||
Human   337 NHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDP 401

  Fly   502 ATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDE 566
            |.:|||.:.|||:||...:|||:||||||||  |||.||.|:|:|::|||:|:.|||:||||.||
Human   402 AGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--CLKSWSWNYYRIVARYENTLAAQFFGHTHVDE 464

  Fly   567 FEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLY 631
            ||:|||...|:.|..:|::.||.:.|..||||||:|.:||::..::.:|:|||::|:||.:||:.
Human   465 FEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIP 529

  Fly   632 G-YPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRL 695
            | .|.|..||.||..|.:....|:.|:||:..:..:.:||:.::..|.|..|....|...|:...
Human   530 GAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLAT 594

  Fly   696 ICDCRSGRSHDRKHFCAEV--ESKIDEESS 723
            :|...|.|: |....|..:  :..:.|..|
Human   595 LCAQLSARA-DSPALCRHLMPDGSLPEAQS 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797	20/71 (28%)
		MPP_ASMase	301..600	CDD:277321	153/299 (51%)
		ASMase_C	584..697	CDD:466022	40/113 (35%)
SMPD1	NP_000534.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SapB	89..162	CDD:214797	23/102 (23%)
		MPP_ASMase	203..498	CDD:277321	153/299 (51%)
		ASMase_C	476..597	CDD:466022	42/120 (35%)