DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3376 and SMPD1

DIOPT Version :9

Sequence 1:NP_001246491.1 Gene:CG3376 / 37884 FlyBaseID:FBgn0034997 Length:764 Species:Drosophila melanogaster
Sequence 2:NP_000534.3 Gene:SMPD1 / 6609 HGNCID:11120 Length:631 Species:Homo sapiens


Alignment Length:680 Identity:254/680 - (37%)
Similarity:362/680 - (53%) Gaps:91/680 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 GKCWLILVLMAVLPLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRT 114
            |..|:.|||...|       ||.........::.|.            |....| |.|..||.|.
Human    29 GLLWMGLVLALAL-------ALALALALSDSRVLWA------------PAEAHP-LSPQGHPARL 73

  Fly   115 HRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIEN 179
            ||          .:.||               .||.|...|..|                     
Human    74 HR----------IVPRL---------------RDVFGWGNLTCP--------------------- 92

  Fly   180 SVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVL 244
              :.|...||...|   |:.:....:..:..|::    |..|.|....|||.:..||..:::.|.
Human    93 --ICKGLFTAINLG---LKKEPNVARVGSVAIKL----CNLLKIAPPAVCQSIVHLFEDDMVEVW 148

  Fly   245 KRVNLSPDELCSFVIGDGCA--DVYNPYHEWEVIFPPVPKPPRLPDLPIPMEAAPFFKVLHISDT 307
            :|..|||.|.|..::|..|.  |:::   .|.:..|.|||||..|..| |...||..::|.::|.
Human   149 RRSVLSPSEACGLLLGSTCGHWDIFS---SWNISLPTVPKPPPKPPSP-PAPGAPVSRILFLTDL 209

  Fly   308 HYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDTPKRTVDHMLSHIAETHKDID 372
            |:|..|.||::.||.:|||||..||.|......||.||:|.|||.|.||::.:||.:... ...|
Human   210 HWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPA-GPFD 273

  Fly   373 YILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPG-VPIFPALGNHESAPVNSFPPPYVNQV 436
            .:.||||:|.||||:||:::.|..: .||..:|..|.| ||::||:|||||.||||||||:: :.
Human   274 MVYWTGDIPAHDVWHQTRQDQLRAL-TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFI-EG 336

  Fly   437 DISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP 501
            :.|..|||:.:...|..|||.....|:|.|.||::...||.|:||||||:|:.:|:|||:|||||
Human   337 NHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDP 401

  Fly   502 ATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDE 566
            |.:|||.:.|||:||...:|||:||||||||  |||.||.|:|:|::|||:|:.|||:||||.||
Human   402 AGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--CLKSWSWNYYRIVARYENTLAAQFFGHTHVDE 464

  Fly   567 FEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLY 631
            ||:|||...|:.|..:|::.||.:.|..||||||:|.:||::..::.:|:|||::|:||.:||:.
Human   465 FEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIP 529

  Fly   632 G-YPIWYKLYTARAAYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRL 695
            | .|.|..||.||..|.:....|:.|:||:..:..:.:||:.::..|.|..|....|...|:...
Human   530 GAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLAT 594

  Fly   696 ICDCRSGRSHDRKHFCAEV--ESKIDEESS 723
            :|...|.|: |....|..:  :..:.|..|
Human   595 LCAQLSARA-DSPALCRHLMPDGSLPEAQS 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3376NP_001246491.1 SapB 186..258 CDD:214797 20/71 (28%)
Metallophos 299..563 CDD:278574 134/264 (51%)
MPP_ASMase 301..600 CDD:277321 153/299 (51%)
SMPD1NP_000534.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
SapB 89..162 CDD:214797 23/102 (23%)
MPP_ASMase 203..498 CDD:277321 153/299 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149493
Domainoid 1 1.000 302 1.000 Domainoid score I1403
eggNOG 1 0.900 - - E1_KOG3770
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H457
Inparanoid 1 1.050 474 1.000 Inparanoid score I1508
Isobase 1 0.950 - 0.543564 Normalized mean entropy S3573
OMA 1 1.010 - - QHG53732
OrthoDB 1 1.010 - - D1142100at2759
OrthoFinder 1 1.000 - - FOG0000551
OrthoInspector 1 1.000 - - oto90450
orthoMCL 1 0.900 - - OOG6_101180
Panther 1 1.100 - - LDO PTHR10340
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R975
SonicParanoid 1 1.000 - - X1866
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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