DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3376 and smpdl3a

DIOPT Version :9

Sequence 1:	NP_001246491.1	Gene:	CG3376 / 37884	FlyBaseID:	FBgn0034997	Length:	764	Species:	Drosophila melanogaster
Sequence 2:	NP_001025618.2	Gene:	smpdl3a / 595006	XenbaseID:	XB-GENE-955002	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	472	Identity:	142/472 - (30%)
Similarity:	212/472 - (44%)	Gaps:	82/472 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 PIPMEAAPFFKVLHISDTHYD--PHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGDYRKCDT 352
            |...|.|..|  .||||.|.|  .|..|.....|       |||......|  .|.:||: .||:
Frog    27 PTQEETAGQF--WHISDLHLDFSYHITEDRTKVC-------LSSKGAKASN--PGIFGDF-VCDS 79

  Fly   353 PKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMV----EMFPGVPI 413
            |...:...:.:|.::|:.:|:::||||.|||   ...||.:..|:.|.:..|.    .:.|.:.:
Frog    80 PYELILSAIQYIKDSHQKVDFMIWTGDSPPH---IPVKELSTKIVIDVIGNMTSTIRSLLPDLLV 141

  Fly   414 FPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRP--- 475
            |||||||:..|.:..|        :..|.:|..:...|:.||.:....|.|:|.:||.:.:.
Frog   142 FPALGNHDYWPQDQLP--------VKESEVYTAVAEFWKPWLTEEALSTFRKGGYYSQIYKSNKS 198

  Fly   476 --GFRIISLNMN--YCNNKNWWLLLNSTDPATELQWFIYELQSAEFSNEKVHVIGHIPPGHSDCL 536
              ..||||||.|  |..||   :.:|.||||.:.:|....|:.:..:||||::|.|:|.|:....
Frog   199 AHSLRIISLNTNLYYTPNK---VTVNMTDPANQFEWLEDTLKISRQNNEKVYIIAHVPVGYLPFA 260

  Fly   537 KV-------WSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYD 594
            ::       ::....||...|...:|||||||||.|...:..|  :...|.|..::.|:|:|...
Frog   261 RLTPAMRETFNERLVKIFRNYSDVITAQFYGHTHRDSIMVLLD--EKEKPVGSVFVTPAVTPIRS 323

  Fly   595 L------NPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYPIWYKLYTARAAYNMKALRP 653
            .      |||:|:|    .:|.|...::|...:.:||.||||.....|...|.....|.:|.|:|
Frog   324 ALETDSNNPGFRLY----QYDTTDYHLLDLWHYFLNLTEANLKNESSWNLEYIMTKTYQIKDLQP 384

  Fly   654 SDWNNLLNELTNNQEL-FELYYKYYWKNSPARPTCDAECKKRLICDCRSGRSHDRKHFCAEVESK 717
            .....|:......:.: |..|||.|..:..:|..||..||.:.||..:                .
Frog   385 ESLEGLVKRFQQPESIEFLYYYKNYLVSFDSRVGCDPLCKLQQICAIQ----------------Y 433

  Fly   718 IDEES-------SKSWK 727
            :||||       ||.:|
Frog   434 VDEESYTKCIIGSKEFK 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3376	NP_001246491.1	SapB	186..258	CDD:214797
		Metallophos	299..563	CDD:278574	90/283 (32%)
		MPP_ASMase	301..600	CDD:277321	101/324 (31%)
smpdl3a	NP_001025618.2	MPP_ASMase	36..335	CDD:277321	102/326 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D1142100at2759
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960